Palmitoylation on conserved and nonconserved cysteines of murine IFITM1 regulates its stability and anti-influenza A virus activity. 来自 国家科技图书文献中心 喜欢 0 阅读量: 50 作者:JC Hach,T Mcmichael,NM Chesarino,JS Yount 摘要: The -induced transmembrane (IFITMs) restrict by numerous , yet...
Palmitoylation on con- served and nonconserved cysteines of murine IFITM1 regulates its stability and anti-influenza A virus activity. J Virol (2013) 87:9923-7. doi:10.1128/ JVI.00621-13Hach JC, McMichael T, Chesarino NM, Yount JS. 2013. Palmitoylation on conserved and nonconserved ...
Here, we report that murine IFITM1 (mIFITM1) is palmitoylated on one nonconserved cysteine and three conserved cysteines that are required for anti-influenza A virus activity. Additionally, palmitoylation of mIFITM1 regulates protein stability by preventing proteasomal degradation, and modification of...
However, inhibition of protein palmitoylation has led to few new drugs to date. ZDHHC5 serves as a key enzyme to catalyze palmitoylation on SSTR5 (a proven anti-proliferation receptor in pancreatic cells). Herein, we compare single-cell transcriptome data between pancreatic cancer tissues and ...