Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?" Gene Ther 13(6 - Weiler, Hunziker - 2006 () Citation Context ...dentification of specific miRNAs involved in tumorigenesis (in both normoxic and hypoxic conditions) it is deemed feasible to inhibit ...
The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 26 nucleobases which are complementary to human microRNAs selected from
Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Matsubara,Takeuchi,Nishikawa,... - 《Oncogene》 - 2007 - 被引量: 725 The Polycistron...
Anti-miRNA oligonucleotides (AMOs): Ammunition to target miRNAs implicated in hu- man disease? Gene Ther 2006;13:496-502.Weiler J, Hunziker J, Hall J. Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Ther. 2006;13:496 -502....
Lima JF, Cerqueira L, Figueiredo C, Oliveira C, Azevedo NF. Anti-miRNA oligonucleotides: a comprehensive guide for design. RNA Biol 2018;15:338-352.Lima, J.F.; Cerqueira, L.; Figueiredo, C.; Oliveira, C.; Azevedo, N.F. Anti-miRNA oligonucleotides: A comprehensive guide for design. ...
Improved performance of anti-miRNA oligonucleotides using a novel non-nucleotide modifier. Mol. Ther. Nucleic Acids 2013, 2, e117.Lennox KA, Owczarzy R, Thomas DM, Walder JA, Behlke MA (2013) Improved performance of anti-miRNA oligonucleotides using a novel non-nucleotide modifier. Mol Ther ...
Hall, "Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?" Gene Therapy, vol. 13, no. 6, pp. 496-502, 2006.Weiler,J., Hunziker,J. and Hall,J. (2006) Anti-miRNA oligonu- cleotides (AMOs): ammunition to target miRNAs implicated in human ...
(Nucleic Acids Res 31:4973–4980, 2003) who used antisense 2′-deoxyoligonucleotides to sequence-specifically inactivate miRNAs in microinjected D. melanogaster embryos. Since then, AMO technology has undergone many important modifications to enhance the efficiency and specificity of miRNA interference. ...
Anti-miRNA oligonucleotides (AMOs) appear to work primarily through a steric blocking mechanism of action; these compounds are synthetic reverse complements that tightly bind and inactivate the miRNA. A variety of chemical modifications can be used to improve the performance and potency...
Our purpose was to identify several functional miRNAs as potential drug targets by using specific antisense-microRNA oligonucleotides (AMOs), and to study the inhibitory effects of these AMOs on A549 cell growth. miR-16, miR-21, miR-214, and miR-181a were selected as target candidates, based...