Extraction and LC/MS Analysis of Oligonucleotide Therapeutics from Biological Matrices Using Clarity® OTX™ SPE and Clarity Oligo-MS™ HPLC/UHPLC ColumnsAdditional studies were undertaken to better understand some of the factors in sample recovery. A speed-vac evaporator is typically used to ...
Oligonucleotide analysis, new practical advances and tips to a mature technique The future of oligonucleotide analysis, from short synthetic DNA to mRNA sequencing Optimizing LC-MS methods for oligonucleotide analysis Advancement of Analytical technology ...
The future of oligonucleotide analysis, from short synthetic DNA to mRNA sequencing Optimizing LC-MS methods for oligonucleotide analysis Advancement of Analytical technology for oligonucleotide analysis using high-resolution accurate-mass mass spectrometry ...
We offer a wide array of analytical technologies & workflows to enable the synthetic chemist & analytical scientist to meet Oligonucleotide analysis challenges
OligoWorks WAX sorbent is quality control tested and batch-selected for maximum oligonucleotide recovery, and a robust detergent-free protocol reduces method development and produces a clean concentrated eluate that is ready for direct LC-MS analysis - avoiding the need for evaporation and reconstitution...
Target prediction analysis for the miRNAs that showed the biggest alteration following corticosterone - miR-124 and miR-218 - revealed critical genes that earlier been reported to be associated with MDD and stress-related disorders, include: glucocorticoid receptors (NR3C1 and NR3C2), and BDN...
LC, LC/MS USP Classification L1 Inner Diameter 50 mm Length 150 mm Carbon Load 18 % UNSPSC 41115709-High pressure liquid chromatography HPLC columns Application Oligonucleotide Brand XBridge Product Type Preparative Columns Units per Package
Although the present study was conducted using nanospray MS, ETD sequencing of heteroconjugates should be compatible with on-line LC-MS/MS analysis [33]. Based on these studies, several predictions regarding radical-driven fragmentation of peptide:oligonucleotide heteroconjugates can be made and ...
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(C) LC-MS/MS analysis of Prk incorporated via AGT codon in eGFP using tRNAPylACU, PylRS and PrK. The mass of the detected peptide of 634.33 Da is close to the calculated mass for PrK-modified peptide (634.26 Da). (D) Reassignment of AGT codon to AzF using eGFP template from (B)....