F. KuehnelS. KubickaElsevier B.V.Journal of HepatologyZender et al., " Small interfering RNA (SIRNA) and Antisense oligonucleotides (ASO) for Reversion of chemotherapy resistance in hepatoma cells, " Journal of Hepatology, vol. 38, Suppl. 02, (Apr. 1, 2003)....
2、Chen Y, Xu N, Hu Z. [Research progress in transdermal delivery for small interfering RNA]. Sheng Wu Gong Cheng Xue Bao. 2020 Apr 25;36(4):622-631. 3、Ita K. Dermal/transdermal delivery of small interfering RNA and antisense oligonucleotides- advances and hurdles. Biomed Pharmacother. ...
与单链反义寡核苷酸(antisense oligonucleotides,ASO)不同,siRNA是短的双链RNA (dsRNA),由一条与靶RNA具有相同序列的正义链,及一条互补引导(反义)链组成。在被细胞摄取后,siRNA与RNA诱导沉默复合物(RISC,一个由AGO2内切酶、反式激活应答RNA结合蛋白2和DICER1组成的多蛋白系统)相互作用,正义链被清除,引导链(反义...
Antisense oligonucleotides,反义寡核苷酸。单链,分子量相对较小约6kDa。主要通过mRNA silencing、抑制ribosome翻译蛋白、调节RNA splicing等机制治疗疾病。 siRNA Small interfering RNA,小分子干扰RNA。通常以双链形式存在,单链形式起效。分子量居中,约13kDa。主...
1)ASO:后缀“-rsen”; 2)siRNA:后缀“-siran”; 3)mRNA:后缀“-meran”,例如新冠疫苗tozinameran(辉瑞+BioNTech)、elasomeran(Moderna)。ASOAntisense oligonucleotides,反义寡核苷酸。单链,分子量相对较小约6kDa。主要通过mRNA silencing、抑制ribosome翻译蛋白、调节RNA splicing等机制治疗疾病。
[4]Melvin M. Evers, Lodewijk J.A. Toonen, Willeke M.C. van Roon-Mom Antisense oligonucleotides in therapy for neurodegenerative disorders.Advanced Drug Delivery Reviews 87 (2015) 90–103. [5]H.B. Kordasiewicz, L.M. Stanek, E.V. Wancewicz, C. Mazur, M.M. McAlonis, K.A. Pytel...
58. Scanlon KJ. Anti-genes: siRNA, ribozymes and antisense. Curr Pharm Biotechnol. 2004;5:415–20. 59. de Martimprey H, Vauthier C, Malvy C, Couvreur P. Polymer nanocarriers for the delivery of small fragments of nucleic acids: oligonucleotides and s...
(Figures 2 and 3). In general, the DNA oligonucleotides consist of a 19-nucleotide sense siRNA sequence linked to its reverse complementary antisense siRNA sequence by a short spacer. Ambion scientists have successfully used a 9-nucleotide spacer (TTCAAGAGA), although other spacers can be ...
目前有四种主流的核酸平台技术,分别是反义寡核苷酸(Antisense Oligonucleotides,ASO),配体修饰的小干扰RNA偶联物(Ligand-modified Small Interfering RNA Conjugates),脂质纳米颗粒(Lipid Nanoparticles,LNP)和腺相关病毒载体(Adeno-associated Virus Vectors,AVV)。
Polymersome delivery of siRNA and antisense oligonucleotides J. Control. Release, 134 (2) (2009 Mar 4), pp. 132-140 View PDFView articleView in Scopus [146] J.D. Heidel Linear cyclodextrin-containing polymers and their use as delivery agents Expert Opin. Drug Deliv., 3 (2006), pp. 641...