ADC解决了超强效细胞毒药物在人体内由于没有选择性的毒性问题,使得这些强效细胞毒药物有了用武之地,同时也为肿瘤的靶向治疗提供了更多的选择和手段。通过了解ADC药物载药的结构和机制特点,以及载药对ADC药物不良反应的影响,有利于在临床实践中选择相关药物以及管理其可能出现的不良反应。作为ADC药物最核心的组成部分之一...
其中周围神经病变在许多使用微管抑制剂的ADC中都能观察到,但在MMAE中最为明显。载药为DM1的ADC药物一致报告血小板减少症和肝毒性;载药为MMAF、DM4的ADC药物则报告眼毒性。并且尽管大多数与眼毒性相关的ADC药物含有MMAF或DM4,但使用MMAE和DM1的ADC也能观察到眼...
Mersana Therapeutics是一家专注于发现和开发针对高需求癌症领域的抗体药物偶联物(ADC)管道的公司。 2022年8月8日,Mersana Therapeutics, Inc.(纳斯达克股票代码:MRSN)宣布,它已与葛兰素史克知识产权(第4号)有限公司(“GSK”)就公司的XMT...
Anti-HER2-ADC bei Brustkrebsdoi:10.1007/s15004-019-7256-8RedaktionSpringerOnkologieSpringerInFo Hmatologie + Onkologie
Similar results on HER237 and TF38 (tissue factor) specific antibody-drug conjugates (ADC) have been reported by comparing the ADC efficacy on cultured cells in IgG and Fab form. However, the data also suggest that the bivalent enhancement of immunotoxin cytotoxicity is antibody-dependent, i.e...
ARX788 is an anti-HER2 antibody drug conjugate (ADC) developed using Ambrx proprietary Engineered Precision Biologics technology. The manufacturing process of ARX788 has been optimized during the course of early to late-phase clinical development. A comprehensive evaluation...
Disitamab vedotin, a novel humanized anti-HER2 antibody-drug conjugate (ADC), combined with toripalimab in patients with locally advanced or metastatic uro... 4566#Background:Disitamab vedotin has shown promising data across a spectrum of HER2 expression in patients with locally advanced or metas...
Object: To prepare an antibody drug conjugate( ADC) with Her2 antibody and MMAE. And to test the effect of this ADC on growth,apoptosis and cell cycle of breast cancer cell. Method: Anti-Her2 monoclonal antibody PH was conjugated with MM... DY She,JH Huang,DC Liu,... - 《China Biote...
(9) 单采和清淋预处理给药前4周内接受过抗体治疗(包括PD-1/PD-L1单克隆抗体)和ADC治疗; (10) 在单采前4周内使用过免疫刺激或免疫抑制治疗(如干扰素-α、干扰素-β,IL-2、依那西普、英夫利昔单抗、他克莫司、环孢素或麦考酚酸); (11) 在单采前4周内进行放射治疗,但有限局部姑息放疗除外; ...
In another aspect, the invention provides immunoconjugates, or antibody-drug conjugates (ADC), comprising an antibody conjugated to a cytotoxic agent such as a chemotherapeutic agent, a drug, a growth inhibitory agent, a toxin (e.g., an enzymatically active toxin of bacterial, fungal, plant, ...