fatty acid synthaseTNFtumor necrosis factortumor necrosis factorPARPPoly (ADP-ribose) polymerasePoly (ADP-ribose) polymeraseHuman FASN is the key enzyme required for de novo synthesis of fatty acids. Up-regulated FASN expression has been reported in various human cancers and was thought to ...
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 2003;63(21):7330–7. CAS PubMed Google Scholar Kuhajda FP, Pizer ES, Li JN, et al. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci USA. ...
上海玉博生物科技有限公司 主要致力于“PIERCEPA112758Anti-Fatty Acid 2-hydrolase Polyclonal Antibody100 µg4999 100 µg”的生产销售。多年的“PIERCEPA112758Anti-Fatty Acid 2-hydrolase Polyclonal Antibody100 µg4999 100 µg”生产与销售的经验,与各行
Subsequently, IFN-I up-/downregulates expression of particular genes to block viral infection. Fatty acid synthase (FASN), the sole enzyme involved in de novo fatty acid synthesis is downregulated possibly by IFN-I upon viral infection. We have shown that FASN deficiency or suppression by ...
Horton JD, Goldstein JL, Brown MS (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109(9):1125–1131 Article Sagar NM et al (2016) Mechanisms of triglyceride metabolism in patients with bile acid diarrhea. World J Gastroe...
Discussion In this study, we demonstrated that Rb2 could enhance the anti-inflammatory effect of ω-3 fatty acid in LPS-stimulated RAW264.7 cells by upregulating GPR120 expression. We fur- ther explored the GPR120 downstream signaling pathways involved in this enhancing effect of Rb2 and ...
expression (Fig.4). In this context, it should also be mentioned that several FABP4 ligands, such as ibuprofen and arachidonic acid31,32, also behave as PPARγ agonists/ligands33,34. The high affinity of FABP4 for bindarit and the high similarity of its binding pocket to that of ...
(1.62 mM); Caproic acid; IC50 = 61.56% (2.23 mM)]. THP-1 macrophages cells were treated withE. coliKUB-36 metabolites and its individual SCFA for 3 h before exposure to LPS for 6 h. Inflammatory cytokine gene expression was expressed relative to THP-1 macrophages cells stimulated by...
We concluded that the anti-adiposity function of BMSO was solely attributed to the fatty acid fraction, with the free fatty acid form having the greatest effect.Background Obesity, a complex metabolic disorder, is the leading chronic disease affecting people of all ages. Effective and safe agents...
Inhibition of 5-Lipoxygenase, FLAP and Cysteinyl LT1 protein expression by 5-Loxin: The effect of 5-Loxin on the key intermediary proteins of arachidonic acid mediated inflammatory pathway was assessed in LPS induced-THP-1 human-monocyte-macrophage cells in vitro. Briefly, THP-1 human monocyte-...