IgG anti-(U1)RNP antibodies were found in the sera of 29 out of 32 patients (90.6%): 21 (65.6%) reacted with the 70-kD protein, 25 (78.1%) with A, 23 (71.9%) with C and 20 (62.5%) with B/B' proteins. None were reactive with the Sm-D peptide. Seventy kilodalton antibody ...
Anti-RNP antibodies are directed against the U1-ribonucleoprotein of the ribonucleoprotein multienzyme complex. The presence of specific antibodies to U1-RNP can help confirm a suspected diagnosis of an autoimmune disease: Anti-RNP tests are positive in 95-100% of sera from patients with mixed ...
Monospecific tests were also performed using the ELISA method to detect anti-double-stranded DNA (anti-dsDNA), anti-Sm, anti-SS-A/Ro, anti-SS-B/La, anti-nucleosome (anti-NuA), anti-ribosomal P protein, anti-histone, and anti-U1-RNP antibodies (EUROIMMUN AG Medizinische Labordiagnostika ...
Numerous autoantibodies may be associated with IIM, e.g., antisynthetase antibodies, myositis-specific antibodies, and myositis-associated autoantibodies, including anti-Ro/SSa, anti-U1RNP 70 kDa, anti-PM/Scl 75 and 100 kDa, and anti-Ku antibodies [12]. Anti-PM/Scl and anti-Ku autoantibodies...
Mixed connective tissue disorder(MCTD) is an overlap syndrome with features of RA, SLE, scleroderma, and DM/PM, which do not meet the criteria for the individual disorders, in the presence of anti-ribonucleoprotein (anti-RNP) antibodies on ENA testing, directed against U1RNP, which is r...
4) Anti-RNP antibodies (Speckled or Nucleolar Pattern) a) Specifically for the differential diagnosis of: 1. Systemic rheumatic diseases 2. Follow-up analysis of collagen vascular disorders 5) Anti-SSA and Anti-SSB (Speckled Pattern) a) Valuable when a patient is anti-nuclear antibody ...
In (NZB×NZW)F1mice,anti-histone antibodiesare readily produced and linked to anti-DNAantibody production, similar to what has been observed in humans[27]. The same is true for example in MRL-lpr/lpr mice, in which anti-DNA antibodies were detected at the age of 4 weeks, whereas anti-...
The present invention relates to a method of inducing the production of anti-HIV antibodies. The method comprises administering at least one liposome-peptide conjugate, wherein the
Keywords: antinuclear antibodies; autoantibodies; auto- immune diseases; HEp-2 cells; immunofluorescence; laboratory diagnostics; methods; microscopy; standardization. Einleitung Nicht organspezifische Autoantikörper (AAK) sind gegen hochkonservierte Antigene körpereigener Zellen gerichtet [1]. Diagnos...
Anti-PM/Scl antibodies are associated with polymyositis (PM)/systemic scleroderma (SSc) overlap syndromes and are also found in other systemic autoimmune diseases. Although anti-PM/Scl reactivity is found in 3-11% of PM or SSc patients and in approximately 25% of PM/SSc overlap patients, prev...