All anti‐U1RNP antibody‐positive infants had classic cutaneous lesions of NLE, but it is of interest that none had congenital heart block (CHB). Although these infants were negative for anti‐Ro and anti‐La antibodies with immunodiffusion and EL ISA techniques, these antibodies might be ...
We report the clinical and serologic features of two infant-mother pairs who are U1RNP antibody positive and Ro (SS-A) antibody negative. HLA typing is reported on these infants, their mothers, and two additional infant-mother pairs with U1RNP antibody-positive lupus whose clinical features ...
Clinical manifestations and anti-(U1)snRNP antibodies: a prospective study of 29 anti-RNP antibody positive patients. Br J Rheumatol 1992, 31, 811–817. PubMed Google Scholar Nimelstein, S.H., Brody, S., McShane, D., Holman, H.R. Mixed connective tissue disease: a subsequent evaluation...
英文翻译anti-U1RNP antibody 名词定义其靶抗原是U1RNP或U1RNP特异性的70K、A或C蛋白,高滴度抗U1RNP抗体为混合结缔组织病(MCTD)的特征性指标(发生率95%～100%)。 所属学科免疫学>免疫系统>免疫分子 名词审定免疫学名词审定委员会 见载刊物《免疫学名词》 科学出版社 ...
(50 mM Tris pH 7.4, 150 mM NaCl, 0,05% ND40). Nuclear extract was prepared from Flp-In-293 cells transfected with ExSpeU1 or mock and was incubated with antibody-coated beads at 4 °C for 4 h. The protein complexes were eluted by boiling with Laemmli buffer and analysed ...
host cells were found to give rise to viral particles endowed with different envelope features, such as the proportion of env protein cleavage and the level of gp120 surface expression; such changes in envelope fea- tures were found to affect viral infectivity, and, possibly, antibody reactivity...
We then assessed whether anti-U1 RNP antibodies could be a prognostic factor in CTD-associated PAH with a focus on SSc-associated PAH.ResultsWe studied a total of 342 patients with CTD-associated PAH, of whom 36 (11%) were anti-U1 RNP antibody positive. Anti-U1 RNP-positive patients were...
As a result, this calls for the extension of these guidelines to include the U1RNP-70kD antibody. In this case, the 70kD subtype of U1RNP was positive, which may have had a role to play in this unusual presentation. However, further research is needed to improve the care of mothers ...
The anti-U1RNP antibody was found in 13 of the 14 patients. There were no significant differences in cerebrospinal fluid findings between the drug-induced group and the non-drug-induced group. Conclusions: SLE or MCTD patients with aseptic meningitis tend to have anti-U1RNP antibody.Okada...
The appearance of U1 RNP antibody specificities in sequential autoimmune human antisera follows a characteristic order that implicates the U1–70 kD and B/B proteins as predominant U1 RNP immunogens. Arthritis Rheum - Greidinger, Hoffman - 2001 () Citation Context ...e representative of two ...