抗U1-snRNP抗体(Anti-U1RNP)测定试剂盒采用胶乳颗粒增强免疫比浊法.将抗原结合到胶乳颗粒上,样本血清(或标准品)中的被测抗体在缓冲液中与胶乳颗粒表面的抗原结合,使胶乳颗粒彼此交联,致使溶液浊度增加,从而检测溶液吸光度增大.在一定范围内,反应液吸光度与被测抗体的浓度呈
抗U1-snRNP抗体(Anti-U1RNP)测定试剂盒(胶乳增强免疫比浊法),上海川至生物技术有限公司,信息来源药智数据国产器械数据库。
Autoantibodies to small nuclear ribonucleoproteins (snRNPs) such as anti-Sm and U1RNP were among the first antinuclear protein responses identified in systemic autoimmune rheumatic diseases (SARD). Anti-Sm antibodies that recognize U1, U2, U5, and U4-6snRNPs are a marker for systemic lupus ...
3、研究表明,抗U1RNP抗体常与抗Sm抗体重叠,抗Sm抗体是系统性红斑狼疮(SLE)的标志性抗体,抗Sm抗体的滴度可能与系统性红斑狼疮(SLE)的活动有关,滴度升高可能预示着系统性红斑狼疮(SLE)的复发;抗U1RNP抗体*早是在混合性结缔组织病(MCTD)患者的血清中发现,高滴度的抗U1RNP抗体是诊断MCTD的必要条件,但并非该病的特...
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Antibodies to U1 ribonucleoproteins (RNP) have been detected in serum from patients with various autoimmune diseases. However, the presence of anti-U1RNP antibodies in patients with localized scleroderma has not been reported. In this study, we examined the frequency of anti-U1RNP antibodies using ...
SUMMARY Anti-UIRNP antibodies occur in patients with mixed connective tissue disease (MCTD), systemic sclerosis (SSc), systemic lupus erythematosus (SLE) and other ill-defined connective tissue diseases. To associate the isotypes of anti-UlRNP antibodies with the diagnosis of the disease, namely ...
However, the role of antibodies to U1-RNP in the pathogenesis of connective tissue disease remains unclear. Data from recent experimental studies promote the hypothesis that U1-RNP antibodies participate in both innate and adaptive immune responses, implicating them in the pathogenesis of connective ...
Twenty-three had U1-(U1--ab). The clinical findings in U1--ab-positive patients were consistent with (MCTD). Disease was more serious in the U1--ab-positive patients in terms of severity as well as mortality due to . Thus, in this patient population, U1--ab positivity predicted an ...
Both speckled antinuclear antibody (ANA) and anti-U1 ribonucleoprotein (RNP) antibody were positive, but anti-double-stranded DNA (dsDNA) antibody and anti-Smith (Sm) antibody were negative, while complement levels were normal. Renal biopsy revealed membranous glomerulonephritis (MGN) with diffuse ...