近日，来自伦敦大学学院癌症研究所的Sergio A. Quezada和克里克研究所的Samra Turajlic在Cancer Cell杂志上发表文章Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma，ADAPTeR II期临床试验招募15例转移性ccRCC病人接受nivolumab（anti-PD-1）治疗，取样115个多区域肿瘤样本，进行综...
GB1211 restored the binding of the anti-PD1/anti-PDL1 therapeutics and may thus reduce tumor resistance to these agents. These findings harmonize excellently withinvivoand clinical data showing an association between Gal-3 expression and lack of efficacy of PD-1/PD-L1 targeted checkpoint ...
近日,来自伦敦大学学院癌症研究所的Sergio A. Quezada和克里克研究所的Samra Turajlic在Cancer Cell杂志上发表文章Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma,ADAPTeR II期临床试验招募15例转移性ccRCC病人接受nivolumab(anti-PD-1)治疗,取样115个多区域肿瘤样本,进行综合分析。
近日,来自伦敦大学学院癌症研究所的Sergio A. Quezada和克里克研究所的Samra Turajlic在Cancer Cell杂志上发表文章Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma,ADAPTeR II期临床试验招募15例转...
程序性死亡受体1(programmed cell death protein 1, PD-1, 又称CD297)是由Pdcd1编码的Ⅰ型跨膜蛋白, 是CD28免疫球蛋白超家族的一员。PD-1表达于多种肿瘤组织中的肿瘤浸润型淋巴细胞, 包括头颈部癌、黑色素瘤和非小细胞肺癌(non-small-cell lungcancer, NSCLC)通过靶向PD-1的免疫治疗可以克服肿瘤环境的免...
Ricciuti, MD, PhD., Genomic and Immunophenotypic Landscape of Acquired Resistance to PD-(L)1 ...
Tumor extracellular matrix has been associated with drug resistance and immune suppression. Here, proteomic and RNA profiling reveal increased collagen levels in lung tumors resistant to PD-1/PD-L1 blockade. Additionally, elevated collagen correlates wit
1.Anti-PD-1抗体治疗导致粒细胞样髓源性抑制细胞的聚集 作者先前的研究发现,在自发的BRAFV600EPTEN–/–黑色素瘤小鼠模型中,anti-PD-1抗体治疗具有短暂的治疗作用,但最终出现免疫逃逸和肿瘤进展。在本研究中,作者收集这些anti-PD-1抗...
D. Acquired resistance to immune checkpoint inhibitors. Cancer Cell 37, 443–455 (2020). Article CAS PubMed PubMed Central Google Scholar Rosenberg, S. A. et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin. Cancer ...
anti-PD-1 T cell receptor TCR clonal maintenance TCR clonal replacement human endogenous retrovirus multiregion autopsy Sorry, something went wrong. Please try again and make sure cookies are enabled Data and code availability Raw bulk whole-exome sequencing, RNA-seq, and TCR-seq data have been...