1.Tumor-Derived Exosomes: Hidden Players inPD-1/PD-L1 Resistance. Cancers (Basel). 2021 Sep; 13(18): 4537.
含有免疫检查点成分的TEX作为免疫治疗的新靶点和液体活检的新生物标记物在临床应用中具有巨大潜力。 参考文献: 1.Tumor-Derived Exosomes: Hidden Players inPD-1/PD-L1 Resistance. Cancers (Basel). 2021 Sep; 13(18): 4537. 更多生物制药知识尽在微信公众号"小药说药", 欢迎大家关注阅览!
近日,来自德国CatalYm公司的Eugen Leo与西班牙纳瓦拉大学的Ignacio Melero共同在Nature期刊发表题为Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours(中和GDF-15能够克服实体肿瘤中抗PD-1和抗PD-L1治疗的耐药性) 的文章。研究报告了GDF-15阻断抗体Visugromab与抗PD-1联合治...
近日,来自德国CatalYm公司的Eugen Leo与西班牙纳瓦拉大学的Ignacio Melero共同在Nature期刊发表题为Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours(中和GDF-15能够克服实体肿瘤中抗PD-1和抗PD-L1...
3. Vautrot V, Bentayeb H, Causse S, et al. Tumor-Derived Exosomes: Hidden Players in PD-1/PD-L1 Resistance[J]. Cancers, 2021, 13(18): 4537. 4.Chen G, Huang A C, Zhang W, et al. Exosomal PD-L1 contributes to immunosuppression and is associated withanti-PD-1response[J]. Nature...
含有免疫检查点成分的TEX作为免疫治疗的新靶点和液体活检的新生物标记物在临床应用中具有巨大潜力。 参考文献: 1.Tumor-Derived Exosomes: Hidden Players inPD-1/PD-L1 Resistance. Cancers (Basel). 2021 Sep; 13(18): 4537.
[1] Gong B, Kiyotani K, Sakata S, et al. Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non–small cell lung cancer[J]. Journal of Experimental Medicine, 2019: jem. 20180870.Yarchoan M, Johnson III B A, Lutz E R, et al. Targeting neoantigens to augment...
[3] Lei Q, Wang D, Sun K, et al. Resistance Mechanisms of Anti-PD1/PDL1 Therapy in ...
Tumor extracellular matrix has been associated with drug resistance and immune suppression. Here, proteomic and RNA profiling reveal increased collagen levels in lung tumors resistant to PD-1/PD-L1 blockade. Additionally, elevated collagen correlates wit
在治疗的过程中可以多留意，以增强免疫治疗效果。癌度祝福各位患者朋友，都能从免疫治疗获益。下载癌度APP，加入免疫治疗交流群，共同交流学习。参考文献 Ilaria Attili, et al.,Strategies to overcome resistance to immune checkpoint blockade in lung cancer, Lung Cancer 154 (2021) 151–160 ...