ANTI-PD-1 THERAPY INDUCED RAPID INNATE INTERFERON RESPONSES DRIVE HIV RESERVOIR DECAYSharma, Ashish ArunkumarTalla, AarthiEnriquez, Ana B.Sanchez, GabrielaPelletier, AdamD'Amico, LeonardChomont, NicolasLewin, SharonDeeks, Steven G.Lurain, Kathryn...
Besides, IL-12 is a proinflammatory cytokine that activates both the innate and adaptive arms of the host immune system. In preclinical investigations, recombinant IL-12 has demonstrated strong antitumor effects [200]. It has been observed that the success of anti-PD-1 therapy relies on the pre...
et al. Cutting edge: prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells. J. Immunol. 191, 540–544 (2013). Article CAS PubMed Google Scholar Namba-Fukuyo, H. et al. TET2 functions as a resistance factor against DNA ...
where the highest expression is found in the first organ/tissue listed, and so on. Tlr3 is able to bind double-stranded RNA, which is a molecular signature of certain viruses. ND not determined
Together, innate and adaptive immune responses are capable of recognizing and destroying cancer. Under selective pressure from the immune response, tumors evolve to escape immune-mediated destruction. Natural killer cells and gamma-delta T cells recogniz
Therefore, translation is not disturbed, and the elevated levels of DHFR mRNA and protein enhance cell proliferation and methotrexate resistance [84]. Altered RNA stability is an important mechanism for A-to-I editing-mediated regulation of gene expression. ADAR1 recruits and interacts with with ...
This T cell-inflamed tumor microenvironment gene signature has been associated with clinical response to therapeutic vaccines, the an- ti-CTLA-4 mAb, and more recently anti-PD-1 mAb [100, 101]. Using immunohistochemical approaches, the pres- ence of CD8+ T cells in the tumor itself or at ...
Rajani K, Parrish C, Kottke T, Thompson J, Zaidi S, Ilett L, Shim KG, Diaz R-M, Pandha H, Harrington K, Coffey M, Melcher A, Vile R (2016) combination therapy with reovirus and anti- PD-1 blockade controls tumor growth through innate and adap- tive immune responses. Mol Ther 24...
18, used BalbC nude (Foxn1 mutation) mice, which lack a thymus and functional B cells, whereas Rag1−/− mutants lack mature B and T cells34. Nevertheless, analysis of the F4/80+CD80+ macrophages, showed that SW480 tumors were more enriched in “M1-like” anti-tumoral macrophage ...
anti-tumor N1 type and the pro-tumor N2 type.91However, in most tumors, the extent of neutrophil infiltration is associated with a poor prognosis.92Tumor cells induce the pro-tumoral transformation of neutrophils by secreting cytokines. For example, tumor cells induce PD-L1 expression in TANs ...