neutralizing anti-drug antibodyHMSAACEBackground: The measurement of anti-drug antibody (ADA) levels in adalimumab (ADAL)-treated and infliximab (IFX)-treated patients is critical for guiding therapeutic strategies. The homogeneous mobility shift assay (HMSA) and affinity capture elution (ACE) assay...
Breast cancer is the most common cancer in women diagnosed in the U.S. and worldwide. Obesity increases breast cancer risk without clear underlying molecular mechanisms. Our studies demonstrate that circulating adipose fatty acid binding protein (A-FABP,
or in special cases, neutralization of specific amounts of drug. it could be argued that any numerical value of sample neutralizing capacity is quasi-quantitative when using an antibody preparation as a reference standard, because the affinities and nature of the antibodies within the standard are ...
novel technologies, quantification of neutralizing antibodies ‐ and biologically active drugmonoclonal antibody therapeutics ‐ biotechnology‐derived drug products, for diseaseschoosing a DQ‐NAb assay format ‐ decision in using DQ‐NAb assay, a careful assessment...
Measurements of serum concentrations of therapeutic antibodies and anti-drug antibodies (ADA) can support clinical decisions for the management of non-responders, optimizing the therapy. In the present study we compared the results obtained by classical ELISA and a recently proposed surface plasmon reson...
The drug-tolerant assay method enabled to detect anti-drug antibody earlier and regardless of drug level at time of sampling [30]. Further studies showed that the detective rate of anti-drug antibody in the drug-tolerant assay was much higher than that in the drug-sensitive assay (63% vs....
Natalizumab (NZM), a humanized monoclonal IgG4 antibody to α4 integrins, is used to treat patients with relapsing-remitting multiple sclerosis (MS)1,2, but in about 6% of the cases persistent neutralizing anti-drug antibodies (ADAs) are induced leading to therapy discontinuation3,4. To underst...
A neutralizing antibody to the receptor for the advanced glycation end products (anti-RAGE Ab) was developed as a potential treatment of acute and chronic inflammatory conditions. Previous pharmacology studies demonstrated efficacy of the anti-RAGE antibody in the mouse model of sepsis. We examined ...
(9) An antibody against a human CD40, or a functional fragment thereof, having at least one property selected from the following properties (g) to (j) of: (g) neutralizing the action of ligands on CD40; (h) neutralizing or alleviating one or more effects that ligands, which are for ...
SARS-CoV-2-Nluc can be used to measure neutralizing antibody activity in patient sera within 5 hours, and it produces results in concordance with a plaque reduction neutralization test (PRNT). Additionally, using SARS-CoV-2-Nluc infection of A549 cells expressing human ACE2 receptor (A549-h...