Once someone recovers clinically and tests: (A) negative by PCR (no live virus present) and (B) positive by serology test (antibodies to SARS-Cov2 present), they may be asked if they would like to donate CCP. If they agree, they undergo plasmapheresis after which their plasma is then ...
The skilled artisan will realize that conservative amino acid substitutions may be made in JCV neutralizing antibodies to provide functionally equivalent variants of these antibodies, e.g., the variants retain the functional capabilities of inhibiting one or more JCV functions. As used herein, a “co...
Weiland.Development of monoclonal neutralizing antibodies against bovine viral diarrhea virus after pretreatment of mice with normal bovine cells and cyclophosphamide.Journal of Virology. 1989Weiland, E., H.-J. Thiel, G. Hess, and F. Weiland. 1989. Development of monoclonal neutralizing antibodies ...
Lassa fever (LF), caused by Lassa virus (LASV), is a viral hemorrhagic fever for which no approved vaccine or potent antiviral treatment is available. LF is a WHO priority disease and, together with rabies, a major health burden in West Africa. Here we p
Epstein-Barr virus (EBV) is associated with a range of epithelial and B cell malignancies as well as autoimmune disorders, for which there are still no specific treatments or effective vaccines. Here, we isolate EBV gH/gL-specific antibodies from an EBV-
Short in-frame deletions in the second extracellular domain of the cytokine receptor gp130 are the leading cause of inflammatory hepatocellular adenomas (IHCAs). The deletions render gp130 constitutively active. In this study we investigate the intracell
Antibodies were detected using 3.75 μg/mL of Alexa Fluor-488-conjugated secondary antibodies (Jackson ImmunoResearch Laboratories) in 10% normal goat serum with 0.1% saponin. Cells were washed three times with PBS++/0.1% saponin followed by two washes in PBS, and mean cellular fluorescence was ...
We monitored the primary humoral response to human immunodeficiency virus type 1 infection and showed that, in addition to antibodies to p24 and gp41, anti... J Lewis,P Balfe,C Arnold,... - 《Journal of Virology》 被引量: 68发表: 1998年 ...
Selenoprotein P (SeP) functions as a selenium (Se)-supply protein. SeP is identified as a hepatokine, promoting insulin resistance in type 2 diabetes. Thus, the suppression of Se-supply activity of SeP might improve glucose metabolism. Here, we develop a
We first quantified vaccine-induced spike S1 domain-reactive antibodies before vaccination 1 (visit 1), at 2–8 weeks (visit 2) or 4–5 months (visit 3) after vaccination 2 and at 2–8 weeks after vaccination 3 (booster shot; visit 4) in infection-naive individuals with cancer. Individua...