The elicitation of broadly neutralizing antibodies (bnAbs) is considered crucial for an effective, preventive HIV-1 vaccine. Led by the discovery of a new generation of potent bnAbs, the field has significantly advanced over the past decade. There is a wealth of knowledge about the development ...
18. Guthmiller JJ, Han J, Utset HA, et al. Broadly neutralizing antibodies target a haemagglutinin anchor epitope. Nature. 2022;602:314-320. doi:10.1038/s41586-021-04356-8 19. Nachbagauer R, Feser J, Naficy A, et al. A chimeric hemagglutinin-based universal influenza virus vaccine appro...
Huang spoke about the path forward for neutralizing antibody protection after the last attempt in a generation of HIV vaccine development ended in disappointment. The past two decades marked the rise in HIV broadly neutralizing antibodies, with vaccine strategies to induce them.Promising advancesinclude ...
The holy grail in influenza has been kind of the broadly neutralizing vaccine, or broadly neutralizing antibody vaccine. Are we any closer to that? Because it may have then clues for what we could do around Coronavirus. I mean, that's been pursued for a decade or more. >> Adam Lauring...
information as lab-based tests. POC technologies, which will revolutionize medicine, need to be first integrated within hospital laboratories as a part of their infrastructure. When available more broadly, POC methods near to the patients are going to save lives, but also help to prevent chronic ...
Although HIV remains a pervasive epidemic, there have been tremendous advancements and progress in HIV prevention, and the work continues. PART I. ENDING THE HIV EPIDEMIC The Centers for Disease Control and Prevention’s (CDC) initiative of Ending the HIV Epidemic (EHE) in the United States is...
and older populations. Of course, if rigorous research evidence ultimately shows a vaccine to be effective over time, with acceptable side-effects, then such information should be broadly disseminated. Whether or not the existing evidence has reached that threshold is what every one of us must now...
The elicitation of broadly neutralizing antibodies (bnAbs) is considered crucial for an effective, preventive HIV-1 vaccine. Led by the discovery of a new generation of potent bnAbs, the field has significantly advanced over the past decade. There is a wealth of knowledge about the development of...
[ 112 – 114 ]. these epitopes, most of them being of conformational nature, were identified thanks to the isolation of human monoclonal broadly neutralizing antibodies (humonabs) [ 96 , 115 – 118 ] (figure 3 ). they are conserved regions of the hiv-1 envelope glycoprotein such as the ...
The vaccine tested in the IAVI G001 clinical trial was specifically designed to activate certain cells that have the potential to produce bnAbs. “We have to walk the immune system down this path to make broadly neutralizing antibodies,” Feinberg explains, noting that in 97 percent of the par...