buforminAMPK/S6 pathwayproliferationinvasionBuformin is an old anti-diabetic agent and manifests potent anti-tumor activities in several malignancies. In the present study, we aimed to explore the functions of buformin in human cervical cancer. As our data shown, buformin exhibited significant ...
2j). Combined, these results suggest that the suppression of ULK1 activity by phenformin is mediated through the LKB1-AMPK pathway. Mitochondrial inhibitors suppress ULK1 activity through the LKB1-AMPK pathway We wondered if mitochondrial inhibitors, which increase AMPK activity, can suppress ULK1 ...
AMP-activated protein kinase (AMPK) is a master regulator of cellular energetics which coordinates metabolism by phosphorylating a plethora of substrates throughout the cell. But how AMPK activity is regulated at different subcellular locations for preci
Full-length ArticleAdiponectin ameliorates traumatic brain injury-induced ferroptosis through AMPK- ACC1 signaling pathway Author links open overlay panelYufeng Ge a 1, Tinghao Wang a g 1, Qing Hu a 1, Xun Wu a b, Yaning Cai a b, Wendong Xie c, Shenghao Zhang a, Bodong Wang d, Jin ...
(c) Metformin or phenformin inhibits mitochondrial ATP synthesis in tumor cells, promoting cell death. If the LKB1-AMPK pathway was down-regulated in the tumor cells, they would be more sensitive to cell death induced by the biguanides than surrounding normal cells. Full size image The first...
Download: Download full-size image Figure 3. pry-1 Functions Downstream of WNT Ligand mom-2 and Independently of β-Catenin bar-1 to Regulate Life Span (A–C) Life span analysis following RNAi knockdown of pry-1 in WNT pathway mutants, mom-2(or42) (A), cwn-2(ok895) (B), and bar...
El-Mahdy NA, El-Sayad ME-S, El-Kadem AH, Abu-Risha SE-S (2021) Metformin alleviates inflammation in oxazolone induced ulcerative colitis in rats: plausible role of sphingosine kinase 1/sphingosine 1 phosphate signaling pathway. Immunopharmacol Immunotoxicol 43(2):192–202 ...
Therefore, the adiponectin pathway may be a promising candi- date for the development of drugs to treat type-2 diabetes and other obesity-related diseases in which insulin resistance plays a signif- icant pathogenic role. Adiponectin enhances insulin sensitivity in ...
Full size image Anticancer phytochemicals targeting AMPK/PGC-1α signaling pathway Several recent studies have highlighted the modulatory roles of various phytochemicals against AMPK/PGC-1α. Accordingly, alkaloids, phenolic compounds, terpenes/terpenoids, and several miscellaneous compounds have shown potentia...
Hypoxia-inducible factor-1 (HIF-1), consists of a constitutively expressed β-subunit and an inducib-expressed α-subunit [16], is a well-established mediator in hypoxia-response pathway. HIF-1α is accumulated under hypoxic conditions, which activates transcription of target genes involved in an...