In some cell types (PC12, C2C12, COS7) ERK5 is activated through a Ras signaling pathway [34], [48]. This suggests that an oncogenic form of Ras may induce typical morphological changes, loss of contact inhibition, The role of MEK5 in epithelial–mesenchymal transitions (EMT) EMT occurs ...
a human medulloblastoma cell line, display a full responsiveness to Hh pathway [26]. To further confirm this, we used Shh conditioned medium (Shh CM) or cyclopamine to treat Daoy cells. Consistent with previous study, Daoy
Full size image Trametinib promotes the autophagic lysosomal pathway through TFEB The autophagic lysosomal pathway is shown to be transcriptionally regulated by TFEB, of which nuclear localization and transcription factor activity are inhibited through phosphorylation at Ser142 by ERK [27, 57]. We first...
For many years now, it has been known that the Raf/MEK/ERK pathway can phosphorylate Bad on S112 which contributes to its inactivation and subsequent sequestration by 14-3-3 proteins [86]. This allows Bcl-2 to form homodimers and an anti-apoptotic response is generated. Activation of the...
missense or deletion mutations in many solid tumors [44]. The expression of MEK4 was shown to be down-regulated in 75% of cases of serous ovarian cancer [45]. It has been hypothesized that loss of MEK4-p38MAPK signaling cascade may be a relevant pathway associated with tumorigenesis [46]...
Form Liquid Purification Method Protein G purification UNIPROT ID Q02750 Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage Conditions Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 背景介绍 MEK1 is also named as ...
浓度:1000 ug/ml 库存:现货 点击咨询售前客服 点击咨询售后客服 humanWB mouseWB Nat Commun ZFP281-BRCA2 prevents R-loop accumulation during DNA replication. mouseWB ACS Appl Mater Interfaces Near-Infrared Light-Responsive Nanoinhibitors for Tumor Suppression through Targeting and Regulating Anion Channels...
There is no single treatment pathway for patients with NF1-PN; surgery, watchful waiting, and/ or medical treatment are options. Treatment should be individualized based on recommendations from a multidisci- plinary team, considering the size and location of PN, effects on adjacent tissues, and...
Full Name mitogen-activated protein kinase kinase 1 Calculated Molecular Weight 43 kDa GenBank Accession Number BC139729 Gene Symbol MEK1 Gene ID (NCBI) 5604 RRID AB_2881242 Conjugate Unconjugated Form Liquid Purification Method Antigen affinity purification Storage Buffer PBS with 0.02% sodium azide...
Full size image To test the role of MEK/ERK pathway in transcriptional activation of UHRF1 and DNMT1 further, we also treated 12 different cancer cell lines with PD0325901 for 48 hours. We found that for 7 esophageal cancer cell lines PD0325901 treatment down-regulated both UHRF1 and DN...