Amphotericin contains two ingredients, A and B with composition of A having a small toxicity and weak antifungal effect which is not suitable for clinical purposes; Composition B has a strong effect, called as amphotericin B. View all 3.6 Usage 1. The product has strong inhibitory effect on ...
Amphotericin B is effective in treating almost all the kinds of fungi with a low incidence of drug-resistant strains. Its price is also relative low which makes it still exhibit high practical value even after its clinical application for more than 40 years. However, the obvious renal toxicity...
In India, resistance has now become common,26,27 and the treatment of choice for Indian-acquired visceral leishmaniasis is now Ambisome®,28 Abelcet®, Amphocil®,29 which are various forms of amphotericin B.30 The first oral treatment for this condition was miltefosine (Impavido®). ...
Oral drug delivery is the most desirable delivery route being non-invasive, convenient and cost-effective. Endogenously, the SLNs are conducive for enhancing the oral uptake of the therapeutic agent by retaining a solubilized state of the drug in the GIT and favors the formation of mixed micelles...
Amphotericin B is most commonly used to treat serious disseminated yeast and dimorphic fungal infections in immunocompromised hospitalized patients. As additional experience has been gained in the treatment of fungal infections with the newer azoles, the use of amphotericin B has diminished; if azole dr...
Amphotericin B is effective in treating almost all the kinds of fungi with a low incidence of drug-resistant strains. Its price is also relative low which makes it still exhibit high practical value even after its clinical application for more than 40 years. However, the obvious renal toxicity...
Keywords: amorphous solid dispersions; amphotericin B; cyclodextrins polymers; spray-drying 1. Introduction Amphotericin B [AmB] is considered as an old drug with antifungal properties. This active pharmaceutical ingredient was extracted from Streptomyces nodosus and its chemical synthesis was discovered ...