Cohen BE, Amphotericin B membrane action: role for two types of ion channels in eliciting cell survival and lethal effects. J Membr Biol. 2010;238(1-3):1-20.Cohen BE. Amphotericin B membrane action: role for two types of ion channels in eliciting cell survival and lethal effects. J ...
amphotericin Beffectsmode of actionantibioticsLittle is known of the kinetics of yeast cell killing by amphotericin B. This is important in intermittent topical therapies using the polyene antibiotics. Our studies demonstrated that higher concentrations of amphotericin B gave higher killing rates for one...
Amphotericin B Chemical Properties,Uses,Production Pharmacology and mechanism of action Amphotericin(1397-89-3) B is a polyene macrolide antibiotic which was introduced into clinical medicine in 1955. It is primarily used for the treatment of serious systemic fungal infections. It is also used as an...
Amphotericins A and B, antifungal antibiotics produced by a streptomycete. II. The isolation and properties of the crystalline amphotericins. Vandeputte J. et al., Antibiot. Annu. 1955-1956. 1956, 587. Amphotericin B and its new derivatives – Mode of action. Baginski M. & Czub J. Cu...
Mechanism of action of amphotericin B at the cellular level. It's modulation by delivery system. J Liposome Res 1993;3:409-27.Bolard, J., Joly, V., Yeni, P. (1993) J. Liposome Res. 3: pp. 409-427Bolard J., Joly J., V., and Yeni Patrick, Mechanism of action of amphotericin...
两性霉素B(Amphotericin B),CAS NO.1397-89-3,分离自链霉菌(Streptomyces sp.)的一种多烯类抗真菌抗生素,与真菌细胞膜的主要成分-麦角甾醇结合,形成一跨膜通道,导致质膜渗透性的改变和胞质关键内容物如单价离子K+,Na+,Cl-,核苷酸,或氨基酸等的流失,破坏正常代谢,从而引起细胞死亡。细菌因质膜上缺乏甾醇,对两性...
Amphotericin B is an antifungal drug with severe side effects in humans and the availability of structural variants would aid investigations into the mode of action and cytotoxity of the drug. Analogs of related polyketide drugs have been rapidly made by genetic engineering of biosynthetic genes; ...
Amphotericin B and Its New Derivatives -- Mode of Action. Amphotericin B (AmB) is a well known antifungal and antiprotozoal antibiotic used in the clinic for several decades. Clinical applications of AmB, however,... Baginski,M.,Czub,... - 《Current Drug Metabolism》 被引量: 148发表: ...
Biochem/physiol Actions Mode of Action: Interferes with fungal membrane permeability by forming channels in the membranes and causing small molecules to leak out. Antimicrobial spectrum: Yeasts and molds. PackagingPackage size based on amphotericin B ...
Amphotericin B Amphotericin Bis a macrolideantifungalwith the broadest spectrum of action, yet quite toxic. It is insoluble in water; therefore, it is administered either as a colloidal suspension withsodium deoxycholateor packaged in liposomal preparations to reduce toxicity. ...