Mechanism of action of amphotericin B at the cellular level. It's modulation by delivery system. J Liposome Res 1993;3:409-27.Bolard, J., Joly, V., Yeni, P. (1993) J. Liposome Res. 3: pp. 409-427Bolard J., Joly J., V., and Yeni Patrick, Mechanism of action of amphotericin...
Mechanism of action of an anti-Candida drug: amphotericin B and its derivatives, p. 214-238. In R. Prasad (ed.), Candida albicans. Cellular and molecular biology. Springer-Verlag, Berlin, Germany.Bolard J. Mechanism of action of an anti-Candida drug: amphotericin B and its derivatives. ...
Its mechanism of action involves binding to the fungal cell membrane, forming pores that disrupt the integrity of the membrane. This leads to leakage of intracellular components and ultimately the death of the fungal cell. Leishmaniasis Treatment: Amphotericin B is also used in the treatment of ...
Amphotericin B Chemical Properties,Uses,Production Pharmacology and mechanism of action Amphotericin(1397-89-3) B is a polyene macrolide antibiotic which was introduced into clinical medicine in 1955. It is primarily used for the treatment of serious systemic fungal infections. It is also used as an...
Mechanism of action Amphotericin Bbinds to ergosterol in the fungal cell membrane, causing depolarization and increased membrane permeability, leakage of cell contents and cell death. The clinical usefulness of this drug is based on its greater affinity for ergosterol in the fungal cell membrane than...
This review highlights some important aspects of the physicochemical properties of amphotericin B and their utilisation in its quantitative determination in biological fluids. Its mechanism of action is re-appraised in the light of recent results with regard to its effects on the physical and ...
The mechanism of action of acyclovir is depicted in Figure 34-8. The intravenous dosage is based on body weight and the type of the lesion. Generally, 5 to 10 mg/kg of body weight is administered intravenously for a 1-hour period and repeated every 8 hours for 5 to 10 days. Long-...
As stated above, the first mechanism of action described was pore formation after binding to the ergosterol present in the membrane. But it has also been demonstrated that AmB induces oxidative damage in the cells. Moreover, amphotericin B modulates the immune system, and this activity has been...
Its activity seems to be related to a modification of the properties of detergent-resistant microdomains. These results provide new insights into the mechanism of action of amphotericin B and confirm the usefulness of infected cultures in the therapeutic research of transmissible spongiform encephalopath...
This review concentrates mainly on interactions of AmB with lipids and sterols, AmB channel formation in membranes, AmB aggregation, AmB modifications important for understanding its biological activity, and AmB models explaining its mechanism of action. Most of the reviewed studies concern monolayers at...