Subcutaneous administration of amphotericin B has been described as a means to decrease nephrotoxicity while increasing the cumulative dose that can be administered. The following protocol has been used success
Amphotericin B is highly toxic and most patients treated with the drug may experience side effects. Thus its clinical use in leishmaniasis is limited. The reported side effects are largely from patients with fungal infections. After intravenous administration, a series of adverse reactions occur. The...
liposomal amphotericin Baccess to medicationpharmacoeconomicsdeveloping countriesThe social and economic impact of leishmaniasis in Brazil is underestimated. The country has a population of 207.5 million; the annual incidence rates of visceral and cutaneous leishmaniasis are 1.58 and 11.86 per 100 000 ...
Amphotericin B, an actively fungistatic and fungicidal polyene antibiotic derived from a streptomycete, produced a beneficial clinical effect in four patients with coccidioidomycosis when administered intravenously. Toxic side effects of intravenous medication were minimized by slow administration in glucose...
Pre-treatment with diosmin hesperidin ameliorated clearance of creatinine and reduced tubular and oxidative injury. Conclusion Administration of amphotericin B resulted in reduction of renal function with tubular injury, and diosmin hesperidin showing an antioxidant protective effect on the kidneys. 展开 ...
Clinical Management of ABLC Administration in Reference Centers Of the 229 individuals who used the ABLC lipid formulation, 109 (47.6%) did not receive any medication to prevent IRSE, of which 17.4% had some infusion reaction but nevertheless remained without premedication in subsequent dosages. Of...
especially in those patients receiving large amounts (over 5 g) of amphotericin B or receiving other nephrotoxic agents. In some patients hydration and sodium repletion prior to amphotericin B administration may reduce the risk of developing nephrotoxicity. Supplemental alkali medication may decrease ren...
Keywords:Anaphylaxis; Drug; Allergy; Liposomal Amphotericin B; Desensitization Introduction Desensitization is defined as drug tolerance and decrease allergic response to medication. Amphotericin B is an anti-fungal treatment against wide variety of a mold, yeast andLeishmania spp. It works through binding...
1. A pharmaceutical composition suitable for intravenous administration consisting essentially of (a) amphotericin B, (b) a glycerol ether selected from the group consisting of (i) HOCH2 CHOHCH2 OR, (ii) HOCH2 CH(OR1)CH2 OH, and (ii) combinations thereof, wherein R and R1 are ...
The medication error was noticed after she had received 2 doses of amphotericin B deoxycholate, and it was then discontinued. Despite treatment in the intensive care unit, the woman died on the sixth day after admission.Amphotericin B deoxycholate has been reported to produce significant cardiac ...