Amphotericin B is highly toxic and most patients treated with the drug may experience side effects. Thus its clinical use in leishmaniasis is limited. The reported side effects are largely from patients with fungal infections. After intravenous administration, a series of adverse reactions occur. The...
Amphotericin Bis poorly absorbed from the gastrointestinal tract and must therefore be administered parenterally. Following intravenous administration, amphotericin B is highly bound (>90%) to plasma proteins (primarily lipoproteins). The drug is rapidly cleared from the plasma and binds to cholesterol-c...
Pre-treatment with diosmin hesperidin ameliorated clearance of creatinine and reduced tubular and oxidative injury. Conclusion Administration of amphotericin B resulted in reduction of renal function with tubular injury, and diosmin hesperidin showing an antioxidant protective effect on the kidneys. 展开 ...
especially in those patients receiving large amounts (over 5 g) of amphotericin B or receiving othernephrotoxicagents. In some patients hydration and sodium repletion prior to amphotericin B administration may reduce the risk of developing nephrotoxicity. Supplemental alkali medication may decrease renal...
Amphotericin B, which is a membrane-active polyene macrolide antifungal agent, has been the most commonly used therapy for the treatment of life-threatening pulmonary fungal infections and the most thoroughly studied agent for inhalation administration [215]. Liposomal amphotericin B dry ...
The patient inadvertently received intravenous amphotericin B deoxycholate 250 mg (4.3 mg/kg) over 2 hours instead of prescribed liposomal amphotericin B. The medication error was discovered 16 hours after administration. She had normal vital signs at that time and reported abdominal pain and general...
amphotericin B liposome intravenous AMPHOTERICIN/LIPID COMPLEX - INJECTION (AM-foe-TER-i-sin/LIP-id) COMMON BRAND NAME(S):Abelcet, Ambisome, Amphotec USES:This medication is used to treat a variety of serious fungal infections. It is often used in patients who cannot tolerate or who do not...
2-9 mcg/ml after 4mg/kg IV dose administration. T1/2 T1/2 T1/2 25 hrs. Distribution Distribution Distribution Attains lower serum concentration but has greater volume of distribution (vd = 4 L/kg) compared to conventional amphotericin. Increased uptake by the liver and...
detailed the successful use of retrobulbar amphotericin B deoxycholate in ROCM.9 After the administration of retrobulbar amphotericin B in our patient, orbital progression halted and the cerebritis resolved. To our knowledge resolution of cerebritis associated with retrobulbar amphotericin B injection has ...
Clinical Management of ABLC Administration in Reference Centers Of the 229 individuals who used the ABLC lipid formulation, 109 (47.6%) did not receive any medication to prevent IRSE, of which 17.4% had some infusion reaction but nevertheless remained without premedication in subsequent dosages. Of...