After intravenous administration, liposomal amphotericin B achieves a higher peak serum concentration and larger area under the serum concentration-time curve than conventional amphotericin B. The drug appears to be taken up extensively by the reticuloendothelial system. High concentrations of drug are de...
A protocol forsubcutaneous administrationof AMB-D has been reported for treatment ofcryptococcosis,39which may be less costly than IV administration. Sterile injection site abscesses occur in some animals treated using this protocol, so IV administration is preferred if possible. ...
Oral administration of Amphotericin B (AmB) is abstained due to its poor bioavailability and high toxicity. Current intravenous lipid formulations are delivered as 35 mg AmB/kg of body weight, due to its dose dependent nephrotoxicity. In this work, we engineer the electrospun gelatin nanofibers to...
Granulocyte transfusion therapy and amphotericin B: adverse reactions? Am J Hematol. 1989;31(2):102–8. https://doi.org/10.1002/ajh.2830310206. Article CAS PubMed Google Scholar Dana BW, Durie BG, White RF, Huestis DW. Concomitant administration of granulocyte transfusions and amphotericin B ...
The MTDs of Fungizone and AmB-NA, determined at 24 hr, post single-dose intra-venous treatment in the mice, are presented in Table2. Although, the literature suggests 2.0 mg/kg MTD for Fungizone40, however, all the treated mice died within 30–120 min after administration of same dos...
Subcutaneous infusions were generally well tolerated by the animals, although concentrations of amphotericin B in excess of 20 mg/L resulted in local irritation. This protocol enabled the administration of larger, and thus more effective, quantities of amphotericin B without producing marked azotaemia....
The dose protocol evaluated (25mg/m2/48h/three times per week) produces maintenance of AmB plasma levels that were close to that obtained by others authors after administration of liposomal formulations of AmB and that have been demonstrated to be clinically effective....
The parenteral NS1 protein priming-oral Salmonella boosting protocol enhanced both NS1-specific serum IgG response and protective efficacy as compared to mice immunized with each type vaccine alone. Addition of an antifungal antibiotic amphotericin B (AmB) to Salmonella vaccine further enhanced the ...
and resistance to amphotericin B and azoles.AspergillussectionFumigati(A. fumigatus sensu stricto, 62.5%) and sectionFlavi(A. flavus, 20.3%;A. parasiticus, 14%; andA. tamarii, 3.1%) have been identified.AspergillussectionFlaviclinical isolates were more virulent than sectionFumigaticlinical isolate...
For example, biofilms formed on catheters are exposed to high concentrations during the antimicrobial-lock therapy (ALT) [2], while biofilms formed on a prosthesis are exposed to drug concentrations usually reached in serum after the administration of standard doses [3]. Candida spp. biofilm ...