Whether or not to Administer Amphotericin to an Immunosuppressed Patient with Hematologic Malignancy and Undiagnosed Fevert Gottlieb JE, Pauker SG: Whether or not to administer amphotericin B to an immunosuppressed patient with hematologic malignancy and undiagnosed fever. Med Decis Making 1:75-93, ...
(seeWARNINGSandDOSAGE AND ADMINISTRATION). If an overdose is suspected, discontinue therapy and monitor the patient's clinical status (e.g., cardiorespiratory, renal, and liver function, hematologic status, serum electrolytes) and administer supportive therapy, as required. Amphotericin B is not ...
The amphipathic polyene amphotericin B (AMB) for many years has been the "workhorse" of antifungal therapy and considered the gold-standard treatment for most fungal infections due its broad antifungal spectrum of activity. However, it is toxic and difficult to administer, requiring intravenous in...