Initial dose: 1000 mg over the first 24 hours of therapy, delivered by the following infusion regimen: -Loading infusions: 150 mg over the first 10 minutes (15 mg/min), followed by 360 mg over the next 6 hours (1 mg/min) -Maintenance infusion: 540 mg over the remaining 18 hours (...
DEA serum concentrations above 0.05 mg/L are not usually seen until after several days of continuous infusion but with prolonged therapy reach approximately the same concentration as amiodarone. Amiodarone is metabolized to DEA by the cytochrome P450 (CYP450) enzyme group, specifically cytochromes ...
Amiodarone infusion in the treatment of acute atrial fibrillation or flutter: high versus low dose treatment[ J] . Heart,2005,91:964-965. ( 收稿日期:2015-09-28)Tuseth V,Jaatun HJ,Dickstein K,et al.Amiodarone infusion in the treatment of acute atrial fibrillationor flutter:high versus low...
effective dose. Once control has been established the dose should be gradually reduced to the smallest amount that will control symptoms, usually 2-3 mg/kg/day.Amiodaroneincreases digoxin retention in the body and, if the two drugs are used together, the digoxin dose should be reduced by a ...
Methods In this prospective, single-arm cohort study, 46 patients with septic shock and tachycardia were enrolled to receive a loading dose of amiodarone 150mg, then continuous infusion of 1mg/min. The primary outcome was the ability of amiodarone in rate control lower than 95 beats per minute...
Finally, clear recommendations for patient monitoring during amiodarone therapy will be provided, stressing the importance of continuous supervision to minimize associated risks and ensure the treatment’s effectiveness. For the purpose of this review, a comprehensive literature search was conducted using ...
N-desethylamiodarone (DEA) is the major active metabolite of amiodarone in humans. DEA serum concentrations above 0.05 mg/L are not usually seen until after several days of continuous infusion but with prolongedtherapyreach approximately the same concentration as amiodarone. Theenzymesresponsible for ...
2, 3 In a small, randomized controlled trial, intravenous amiodarone, administered as a continuous infusion of 43.75 mg/hour for 96 hours (total dose, 4200 mg), significantly reduced the incidence of AF after esophagectomy.6 The incidence of adverse effects in the amiodarone group was not ...
Introduction The haemodynamic response after an IV-loading dose of amiodarone followed by continuous infusion for various supraventricular and ventricular... NA Haas,CK Camphausen - 《Clinical Research in Cardiology》 被引量: 106发表: 2008年 Hemodynamic effects of intravenous amiodarone in humans The ...
NIF was used in all patients at a mean dose of 0.36 ± 0.13 mg/kg as a bolus and at 0.34 ± 0.09 mg/kg/h as continuous infusion. Neither a terminative nor preventive effect was observed after administration of NIF in any of the patients (NIF-resistance). Intravenous AMD alone (...