Dosing information Usual Adult Dose for Arrhythmias: IV: Initial dose: 1000 mg over the first 24 hours of therapy, delivered by the following infusion regimen: -Loading infusions: 150 mg over the first 10 minutes (15 mg/min), followed by 360 mg over the next 6 hours (1 mg/min) ...
Dosing units differ from concentration unitsTable 2: Standardize 4 Safety Continuous IV Infusion Standard Concentrations for Amiodarone460461 Patient Population Concentration Standards Dosing Units Adults 1.8 mg/mL mg/min Pediatric patients (<50 kg) 1.8 mg/mL mcg/kg/min 3.6 mg/mL ...
Amiodaroneis effective given orally; its enormous apparent distribution volume (70L/kg) indicates that little remains in the blood. It is stored in fat and many other tissues and thet½of 54days after multiple dosing signifies slow release from these sites (and slow accumulation to steady stat...
The recommended dose of amiodarone in this context is a 150 mg bolus, followed by an infusion of 1 mg/min for 6 h, then 0.5 mg/min for 18 h [20]. To pharmacologically terminate a hemodynamically tolerated VT, the ESC recommends either IV amiodarone or procainamide, while the American Co...
although a starting dose adequate to suppress life-threatening arrhythmias is needed, close monitoring with adjustment of dose as needed isessential. The recommended starting dose of intravenous amiodarone is about 1000 mg over the first 24 hours of therapy, delivered by the following infusionregimen...
Dosing The maximum cumulative dose in a 24 hour period should not exceed 2.2 grams. Within the VT/VF pulseless arrest algorithm, the dosing is as follows: 300mg IV/IO push → (if no conversion) 150 mg IV/IO push →(after conversion)Infusion #1 360 mg IV over 6 hours (1mg/min) →...
In addition, IV infusion of MNI-2 alone or after pretreatment with amiodarone did not result in MBP or PR, QRS, QT ECG interval changes (data not shown). Furthermore, cardiac tissues from anesthetized guinea pigs were collected immediately following the end of the MNI-2 and MNI-2+...
Due to recurrent episodes of ventricular tachycardia, supraventricular tachycardia and intermittent atrial fibrillation, he received an IV bolus of amiodarone 150mg followed by continuous infusion at 1 mg/min for 6 hours, and then 0.5 mg/min for 18 hours. He was later switched to oral amiodarone...
Amiodarone adsorbs to polyvinyl chloride (PVC) tubing, but all of the clinical experience has been with PVC tubing and the concentrations and rates of infusion provided in DOSAGE AND ADMINISTRATION reflect dosing in these studies. Amiodarone has been found to leach out plasticizers, including DEHP...
(i) complete suppression of the recurrence of sustained VT/VF or AF during maintenance infusion of the drug, (ii) recurrence during maintenance infusion of the drug but not after increase in the dose of NIF or AMD, (iii) complete suppression, maintenance infusion of the drug, of the ...