Use: Initiation of treatment and prophylaxis of frequently recurring VF and hemodynamically unstable VT in patients refractory to other therapy. ORAL: Loading dose: 800 to 1600 mg orally per day for 1 to 3 weeks (occasionally longer) until adequate arrhythmia control is achieved or if side effect...
High-dose rapid oral loading of amiodarone: caution required in CHFInpharma Weekly -doi:10.2165/00128413-199509930-00040NoneSpringer International PublishingInpharma Weekly
to measures of clinical efficacy, in an effort to optimize therapy. In adults the elimination half-life is over 50 days, and this can result in a slow onset of efficacy, so that normally a loading dose is given over a period of 1 week. Furthermore, it is strongly protein bound and ...
slowly and maximum concentrations are reached three to seven hours after oral administration. Some effects may be seen after two to three days; however, it normally takes between one and three weeks of regular dosing for the full effects of amiodarone to be seen, even with a loading dose. ...
dose for changing from intravenous to oral administration of amiodarone will depend on the dose of intravenous amiodarone already administered, as well as the bioavailability of oral amiodarone. When changing to oral amiodarone therapy, clinical monitoring is recommended, particularly for elderly patients....
The purpose of this prospective randomized study was to compare the electrophysiologic effects of conventional and high dose loading regimens of amiodarone in patients with sustained ventricular tachycardia.Uncontrolled studies in which patients have been treated with an oral loading dose of 2 to 4 g/...
Introduction The haemodynamic response after an IV-loading dose of amiodarone followed by continuous infusion for various supraventricular and ventricular... NA Haas,CK Camphausen - 《Clinical Research in Cardiology》 被引量: 106发表: 2008年 Clinical pharmacology:Amiodarone: an effective antiarrhythmic ...
Reduce dose levels of previously administered antiarrhythmic by 30 to 50% for several days after transitioning to oral amiodarone. Evaluate continued need for antiarrhythmic. Digoxin Increased digoxin concentration. Reduce digoxin by half or discontinue. If continued, monitor for evidence of toxicity. ...
Following oral administration in man, aniodarone is slowly and variably absorbed. The bioavailability of amiodarone is approximately 50% but has varied between 35 and 65% in various studies. Maximum plasma concentrations are attained 3 to 7 hours after a single dose. Despite this, the onset of...
The present study aims to demonstrate the influence of the polymer-carrier type and proportion on the quality performance of newly developed oral immediate-release tablets containing amiodarone solid dispersions obtained by hot-melt extrusion. Twelve solid dispersions including amiodarone and different polyme...