IV: Initial dose: 1000 mg over the first 24 hours of therapy, delivered by the following infusion regimen: -Loading infusions: 150 mg over the first 10 minutes (15 mg/min), followed by 360 mg over the next 6 hours (1 mg/min) ...
Question A patient started on oral (PO) amiodarone approximately 1 week ago (400 mg/day). The patient is now taking nothing by mouth (NPO), and the physician would like to switch to intravenous (IV) amiodarone. The only information that I could find about PO to IV conversion involved pat...
Giving IV and oral amiodarone perioperatively for the prevention of postoperative atrial fibrillation in patients undergoing coronary artery bypass surgery: the GAP study. Chest 2004;126(3):716–724.Kerstein J, Soodan A, Qamar M, Majid M, Lichstein E, Hollander G, Shani J. Giving IV and ...
while classified as a class III antiarrhythmic agent as it prolongs phase III of the cardiac action potential, also has effects similar to antiarrhythmic agents in 1a, II, and IV classes. Amiodarone is used in certain patients withventricular fibrillation,ventricular tachycardia, andatrial fibrillation...
Oral amiodarone takes days to work in ventricular tachyarrhythmias, but iv. amiodarone has immediate effect and can be used in life threatening ventricular arrhythmias. Intravenous amiodarone administered after out-of-hospital cardiac arrest due to ventricular fibrillation improves survival to hospital ...
Although amiodarone is considered a class III anti-arrhythmic agent, it also has class I, II, IV actions, making it a unique and effective anti-arrhythmic agent. Because of its minimal negative inotropic activity and very low rate of pro-arrhythmia, it is considered safe in treating ...
QTcintervals during IV amiodarone therapy.Two patients developed sinal bradycardia and one transitory II atrioventricular block and recovered after decrease of dosage of amiodarone.Phlebitis occurred in 8 patients.Conclusion: Intravenous amiodarone can be used safely and effectively in patients with life-...
Amiodarone is absorbed slowly and maximum concentrations are reached three to seven hours after oral administration. Some effects may be seen after two to three days; however, it normally takes between one and three weeks of regular dosing for the full effects of amiodarone to be seen, even wit...
Patients randomized to placebo received an identical amount of saline IV over 24 hours and then oral placebo for 1 month. Conversion to sinus rhythm was achieved in 16 of the 33 patients (48.5%) who received amiodarone and in none of the 34 patients in the placebo group (p <0.001). ...
The optimal dose for changing from intravenous to oral administration of amiodarone will depend on the dose of intravenous amiodarone already administered, as well as the bioavailability of oral amiodarone. When changing to oral amiodarone therapy, clinical monitoring is recommended, particularly for ...