The partial least‐squares model showed that two baseline metabolites (uridine and guanosine), one single‐nucleotide variation ( VKORC1 ), and four clinical parameters (weight, creatinine level, amiodarone usage, and initial daily dose) had good predictive power for INR day7 ( R 2 = 0.753 ...
Levofloxacin should be avoided in patients with known prolongation of the QT interval, patients with uncorrected hypokalemia, and patients receiving Class IA (quinidine, procainamide), or Class III (amiodarone, sotalol) antiarrhythmic agents. Elderly patients may be more susceptible to drug-associated ...
In addition, the long-term use of sotalol and amiodarone has been associated with increased mortality (OR: 4.32; 95% CI: 1.59-11.70; P = 0.013; and OR: 2.73; 95% CI: 1.00-7.41; P = 0.049, respectively) (8). Conversely, multiple observational studies and randomized controlled trials ...
Other drugs: Amiodarone Amiodarone inhibits peripheral conversion of levothyroxine (T4) to triiodothyronine (T3) and may cause isolated biochemical changes (increase in serum free-T4, and decrease or normal free-T3) in clinically euthyroid patients. 7.2 Antidiabetic Therapy Addition of ERMEZA ther...
Other drugs: Amiodarone Amiodarone inhibits peripheral conversion of levothyroxine (T4) to triiodothyronine (T3) and may cause isolated biochemical changes (increase in serum free-T4, and decrease or normal free-T3) in clinically euthyroid patients. 7.2 Antidiabetic Therapy Addition of ERMEZA ther...
These observations should be considered in clinical decisions to prescribe DETROL LA to patients with a known history of QT prolongation or to patients who are taking Class IA (e.g., quinidine, procainamide) or Class III (e.g., amiodarone, sotalol) antiarrhythmic medications. There has been no...
(e.g., quinidine, procainamide); Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus) [see Drug Interactions (7.7, 7.8) and Clinical Pharmacology (12.3)]...
The concomitant use of transdermal fentanyl with all CYP3A4 inhibitors (such as ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin, nelfinavir, nefazodone, amiodarone, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, verapamil, or grapefruit juice) may result ...
If effects of oral administration drugs such as digoxin, amiodarone and metoprolol were not obvious, with AF staying alive, patients should receive electrical cardioversion therapy. There were 13 cases underwent cardioversion therapy. After admission, ECG monitoring was needed. After intravenous ...
Being female and taking amiodarone were identified as factors that significantly increased the likelihood that the patient's predicted dose would be outside of 20% of their actual therapeutic dose or outside the range of the pharmacogenetic table. Conclusion. Using the pharmacogenetic dosing table ...