In addition, the long-term use of sotalol and amiodarone has been associated with increased mortality (OR: 4.32; 95% CI: 1.59-11.70; P = 0.013; and OR: 2.73; 95% CI: 1.00-7.41; P = 0.049, respectively) (8). Conversely, multiple observational studies and randomized controlled trials ...
These changes in drug pharmacokinetics can arise from a variety of factors, including disease processes (e.g., congestive heart failure, cirrhosis and renal failure), concomitant medications (e.g., hepatic enzyme inducers such as phenytoin and inhibitors such as amiodarone), drug formulation, ...
A few points require further discussion. First, periodic limb movements occur with greater prevalence in older individuals.8Periodic limb movements are not diagnostic of RLS, but in their absence, the diagnosis is less certain. Although amiodarone may be associated with neurologic symptoms, restless l...
These observations should be considered in clinical decisions to prescribe DETROL LA to patients with a known history of QT prolongation or to patients who are taking Class IA (e.g., quinidine, procainamide) or Class III (e.g., amiodarone, sotalol) antiarrhythmic medications. There has been no...
Levofloxacin should be avoided in patients with known prolongation of the QT interval, patients with uncorrected hypokalemia, and patients receiving Class IA (quinidine, procainamide), or Class III (amiodarone, sotalol) antiarrhythmic agents. Elderly patients may be more susceptible to drug-associated ...
We were interested to know whether the TSH-suppressive dose can be predicted on a body weight-or body sur... H Kainz,M Weissel - 《Acta Medica Austriaca》 被引量: 0发表: 1990年 AMIODARONE-INDUCED HYPERTHYROIDISM: ASSESSMENT OF THE PREDICTIVE VALUE OF BIOCHEMICAL TESTING AND RESPONSE TO ...
The concomitant use of transdermal fentanyl with all CYP3A4 inhibitors (such as ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin, nelfinavir, nefazodone, amiodarone, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, verapamil, or grapefruit juice) may result ...
(e.g., quinidine, procainamide); Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus) [see Drug Interactions (7.7, 7.8) and Clinical Pharmacology (12.3)]...
The partial least‐squares model showed that two baseline metabolites (uridine and guanosine), one single‐nucleotide variation ( VKORC1 ), and four clinical parameters (weight, creatinine level, amiodarone usage, and initial daily dose) had good predictive power for INR day7 ( R 2 = 0.753 ...
Being female and taking amiodarone were identified as factors that significantly increased the likelihood that the patient's predicted dose would be outside of 20% of their actual therapeutic dose or outside the range of the pharmacogenetic table.Conclusion. Using the pharmacogenetic dosing table ...