Dosing information Usual Adult Dose for Arrhythmias: IV: Initial dose: 1000 mg over the first 24 hours of therapy, delivered by the following infusion regimen: -Loading infusions: 150 mg over the first 10 minutes (15 mg/min), followed by 360 mg over the next 6 hours (1 mg/min) ...
In general, start at the low end of the dosing range in the elderly to reflect the greater frequency of decreased hepatic, renal, or cardiac function, and concomitant disease or other drug therapy. 10. Overdosage There have been cases, some fatal, of amiodarone overdose. Effects of an ...
Dosing The maximum cumulative dose in a 24 hour period should not exceed 2.2 grams. Within the VT/VF pulseless arrest algorithm, the dosing is as follows: 300mg IV/IO push → (if no conversion) 150 mg IV/IO push →(after conversion)Infusion #1 360 mg IV over 6 hours (1mg/min) →...
During the loading phase of acute intravenous (IV) administration, amiodarone exhibits more class I, IV, and non-selective class II effects, primarily blocking Na+ and Ca+ channels, as well as β-receptors, respectively [12]. The blockade of repolarizing K+ channels, which constitutes the cla...
Amiodarone hydrochloride injection leaches DEHP plasticizer from IV tubing; exposure to DEHP may adversely affect male reproductive tract development during fetal, infant, and toddler stages of development. Consider dosing methods to reduce potential exposure to DEHP....