Objective To study the role of urine leucine aminopeptidase (LAP) for sifting early renal injury in diabetic and hypertension patients. 目的探讨尿亮氨酸氨基肽酶(LAP)筛查糖尿病和高血压病早期肾损害的临床价值。 5. Objective To compare clinical significance of alanine aminopeptidase(AAP) and leucme amin...
Aminopeptidase B (Ap-B), a ubiquitous enzyme, catalyses the amino-terminal cleavage of basic residues of peptide or protein substrates, indicating a role in precursor processing. The physiological function of Ap-B still remains an open question, even though its activity suggests that it could be...
ERAPs play an important role in the N-terminal processing of the antigenic precursors that are presented on the major histocompatibility complex (MHC) class I molecules. ERAPs are also implicated in the regulation of a wide variety of physiological phenomena and pathogenic conditions. In this ...
Peptidases have a central role in the degradation of proteins by hydrolyzing peptide bonds. Based on the reaction catalyzed, these enzymes can be classified as endopeptidases, aminopeptidases or carboxypeptidases. Relative to the endoproteases and carbox
Methionine aminopeptidase (MetAP) catalyzes the removal of N-terminalmethionineresidues from newly synthesizedpolypeptide chains(Lowther & Matthews, 2002). It is known to play a critical role in the growth of new blood vessels, tumors, and metastasis, and thus is a target for the development of...
To review the recent developments in our understanding of endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) function in relation to its role in major histocompatibility complex (MHC) class I peptide presentation and human leukocyte antigen (HLA) class I-associated diseases. ERAP1 polymorphisms exhib...
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours Enkephalins are degraded by the concomitant action of two metallopeptidases: neutral endopeptidase (NEP, EC3.4.21.11) and aminopeptidase N (APN, EC3.4.11.2......
Despite wide variability in steric bulk, chemical composition, and electrical charge of the substituted anilides, the Km values of the above compounds vary over a narrow range (0.5 to 4.8 mm), which indicates that the leucyl moiety plays the predominant role in the determination of Km values. ...
The predominantly cytosolic localization of the enzyme would not be consistent with a primary role in the degradation of extracellular, bioactive peptides. Its broad distribution in rat tissues also argues against a purely neuropeptide-regulative effect. Aminopeptidase PS has been purified essentially to...
Insulin-regulated aminopeptidase in astrocytes: Role in Alzheimer's disease? Background Neuroinflammation occurs in Alzheimer's disease (AD) brains in response to pathological deposition of amyloid beta and subsequent neurodegeneration. Scrutiny of conventional anti-inflammatory drug trials has revealed mixed...