Role of APN in regulation of keratinocyte growth is suggested, as its inhibition resulted in decreased keratinocyte growth.doi:10.1016/j.imlet.2003.10.006Jelka GabrilovacBarbara upiDavorka BreljakMarija ZekuiMi
Ectoenzymes as sites of peptide regulation Aminopeptidase A (EC 3.4.11.7) is an integral membrane, Zn-metallopeptidase that cleaves aspartyl or glutamyl residues from peptides. Aminopeptidase A has been difficult to separate from aminopeptidase N and, like the latter, has been localized to cerebral...
D. & Jones, B. D. Lon protease activity causes down-regulation of Salmonella pathogenicity island 1 invasion gene expression after infection of epithelial cells. Infect Immun 72, 2002–2013, (2004). 50. Takaya, A., Kubota, Y., Isogai, E. & Yamamoto, T. Degradation of the HilC and ...
major histocompatibility complex (MHC) Class I expression at the cell surface was also disparate, and wondered whether this observation might strengthen the evidence between p53 and regulation of immune responses. Appropriate regulation of MHC expression is important for effective tumour surveillance...
Bartling D, Nosek J. Molecular and immunological characterization of leucine aminopeptidase inArabidopsis thaliana: A new antibody suggests a semi-constitutive regulation of a phylogenetically old enzyme. Plant Sci 1994; 9: 199–209. Google Scholar ...
K562/ADR cells exhibited a significant lower level of APN mRNA than K562 cells. On the other hand, high dose of bestatin (100 μM) induced MDR1 upregulation by 49.4% and 18.0% in K562 and K562/ADR cells, respectively. The result confirmed that bestatin was a substrate of P-gp in mRNA...
In addition, it was shown that 100 μg/ml of polyclonal antibody against AgAPN-1 could reduce oocyst formation of Plasmodium berghei in the midgut of An. gambiae. Furthermore, peptide mapping showed that a 135 amino acids fragment located in the N-terminal of AgAPN-1 is immunogenic even ...
NSG mice were untreated, and WT mice were untreated or treated with anti-PD-1 antibody. (E) In vitro NK cell competition cytotoxicity assay for control versus Erap1 KO tumor cells in control, Qa-1b KO, and B2m KO backgrounds. (F) Schematic of Qa-1b/B2m, presenting peptide Qdm, ...
Other examples of biological diagnostic devices, which can be used for the detection of es-LAPase, using the monoclonal antibody of the present invention, include the devices described by G. Grenner, P. B. Diagnostics Systems, Inc., in U.S. Pat. Nos. 4,906,439 and 4,918,025. ...
(ILs), e.g., IL-1 to IL-10; anti-HER-2 antibody; superoxide dismutase; T-cell receptors; surface membrane proteins; decay accelerating factor; viral antigen such as, for example, a portion of the AIDS envelope; transport proteins; homing receptors; addressins; regulatory proteins; ...