Gamma-aminobutyric acid transporter 1 negatively regulates T cell-mediated immune responses and ameliorates autoimmune inflammation in the CNS. J Immunol 2008; 181: 8226–8236. 17. Dionisio L, Jose De Rosa M, Bouzat C, Esandi Mdel C. An intrinsic GABAergic system in human lymphocytes. ...
Potter S.J. Cavanaugh J.A. Rasko J.E. Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19.Nat. Genet. 2004; 36: 1003-1007Crossref PubMed Scopus (210) Google Scholar, 18Kleta R. Romeo E. Ristic Z. Ohura T. Stuart C. Arcos-...
another amino acid transporter expressed in DH44+neurons, showed similar results in blocking the increase in food consumption induced by dietary amino acids (Fig.7b).
In contrast, threo-β-hydroxyaspartate (THA) and by L-trans-pyrrolidine-2,4-dicarboxylic acid downregulates this transporter (Arriza et al., 1997). Show abstract Regulation of the Na+-coupled glutamate transporter EAAT3 by PIKfyve 2009, Neurochemistry International Show abstract Regulation of ...
Unique long 16 binding proteins (ULBPs), otherwise known as retinoic acid early transcripts (RAET) with encoded gene as RAET1, are a family of ligands for NKG2D receptors in humans, which are commonly expressed by tumour cells and facilitate the biological functions of NK cells. Several ...
In the AVT transporter family, Avt1p works for active uptake of amino acid into vacuole, and Avt3p, Avt4p, and Avt6p for active extrusion of amino acid from vacuole to cytosol. Here, we found green fluorescent protein-tagged Avt7p, an unidentified member of the AVT family, localized to...
2012). The activity of the lysosomal proton-assisted amino acid transporter PAT1, responsible for the efflux of amino acids from the lysosomes, may control the concentration of amino acids within the lysosomal lumen and thus the extent of MTORC1 activation (Zoncu et al. 2011), but the ...
(Fig.1b). Subsequently, the neuronal glutamine transporter fromRattus norvegicus, the sodium-coupled neutral amino acid transporter, and intracellular vacuolar amino acid transporters 2 (AVT2) and 6 (AVT6) fromS. cerevisiaewere found to be high-scoring hits in a BLASTP search of the TCDB ...
signal transducers and activators of transcription 3 (STAT3) promote MYC expression in tumor cells in AML, which in turn regulates the transcription of amino acid transporter SLC1A5, promotes Gln metabolism in AML cells, and oxidative phosphorylation (OXPHOS) of leukemia stem cells (LSCs). Small-...
(proton-assisted amino acid transporter 1)), and possibly histidine (SLC15A4) levels to the Rag GTPases, (iii) mammalian Sestrin1 and Sestrin2 that dissociate from GATOR2 when directly bound to leucine or to the lower-affinity substrates methionine and isoleucine and (iv) yeast S-...