PROBLEM TO BE SOLVED: To provide a medicine treating various kinds of clinical conditions such as tumor (cancer), by identifying and isolating a new amino acid transporter molecule mediating the transportation of the amino acids which are essential nutrients for the living and proliferation of ...
The System A amino acid transporter SNAT2/SLC38A2 is ubiquitously expressed in mammalian cells including muscle, performing Na+-dependent active import of neutral amino acids, and is strongly inhibited by low pH. Exposure of rat skeletal muscle cell line L6-G8C5 to low pH rapidly inhibits SNAT...
Recently, two isoforms, LAT-1 (37) and LAT-2 (38, 39), of a subunit of the L transporter have been cloned and characterized. LAT form a heterodimeric complex with 4F2hc, a protein implicated in cationic amino acid transport. This heterodimer appears to be responsible for the L-type of...
(69,70), rendering the transport process electrogenic. The protein responsible for this transport activity has been identified at the molecular level recently (see note added in the proof). It is known asSIT1(sodium-coupled imino acid transporter 1) or IMINO. It is also identified as SLCGA20...
Thus, as a tetraspanin membrane protein, TM4SF5 can form protein complexes with amino acid transporters during pathological cell developments. TM4SF5 regulates ROS levels in lung epithelial cells TM4SF5 binds to the cystine/glutamate transporter, the xc− system consisting of CD98hc and xCT ...
CAT1 and CAT3 belong to amino acid transporter system y+ mediating the sodium and pH independent transport of cationic amino acids which is stimulated by substrate concentration (20). CAT1 is expressed at both gene and protein level at the human BBB (13,14) and is found in both the rat...
Excitatory Amino Acid Transporter 2 (胞外)抗体的免疫原肽段为(C)KQLGPGKKNDEVS。此免疫原序列来源于151-163 位氨基酸残基,该序列来源于大鼠EAAT2 (Accession编号为P31596)。 第二胞外环。 来源宿主 兔 反应性 反应性:人、 小鼠、 大鼠 保存建议
上海玉博生物科技有限公司 主要致力于“Anti-EAAT3(Excitatory amino acid transporters 3) 抗胶质细胞谷氨酸运载蛋白3抗体 yb-1752R”的生产销售。多年的“Anti-EAAT3(Excitatory amino acid transporters 3) 抗胶质细胞谷氨酸运载蛋白3抗体 yb-1752R”生产与销售的经验
Mechanistically, SLC7A5 maintains intracellular amino acid levels following KRAS activation through transcriptional and metabolic reprogramming. This supports the increased demand for bulk protein synthesis that underpins the enhanced proliferation of KRAS-mutant cells. Moreover, targeting protein synthesis, ...
Apicomplexans are obligate intracellular parasites that scavenge essential nutrients from their hosts via transporter proteins on their plasma membrane. The identities of the transporters that mediate amino acid uptake into apicomplexans are unknown. Her