The System A amino acid transporter SNAT2/SLC38A2 is ubiquitously expressed in mammalian cells including muscle, performing Na+-dependent active import of neutral amino acids, and is strongly inhibited by low pH. Exposure of rat skeletal muscle cell line L6-G8C5 to low pH rapidly inhibits SNAT...
CAT1 and CAT3 belong to amino acid transporter system y+ mediating the sodium and pH independent transport of cationic amino acids which is stimulated by substrate concentration (20). CAT1 is expressed at both gene and protein level at the human BBB (13,14) and is found in both the rat...
2.1.2 Large neutral amino acid transporter 1 Another intensively studied transporter system is large neutral amino acid transporter 1 (LAT1) and is expressed both on the luminal and abluminal membranes of BCECs (Roberts et al., 2008; Kido et al., 2001). LAT1 mediates brain uptake of neutra...
Mechanistically, SLC7A5 maintains intracellular amino acid levels following KRAS activation through transcriptional and metabolic reprogramming. This supports the increased demand for bulk protein synthesis that underpins the enhanced proliferation of KRAS-mutant cells. Moreover, targeting protein synthesis, ...
(γ-aminobutyric acid transporter-1), which are critically important for mediating peripheral naive T-cell homeostasis, activation and differentiation, especially for Th1 and Th17 cells, and even memory T cells. Mechanically, the influence of amino-acid transporters on T-cell fate decision may ...
Apicomplexans are obligate intracellular parasites that scavenge essential nutrients from their hosts via transporter proteins on their plasma membrane. The identities of the transporters that mediate amino acid uptake into apicomplexans are unknown. Her
英文名字 Recombinant Vibrio harveyi Probable amino-acid ABC transporter permease protein patM (patM) 供应商 MyBioSource 产品货号 MBS1122863 产品报价 ￥询价/INQUIRE ￥询价/其它规格 产品说明书 点击查看 购买方式 MyBioSource中国区金牌代理,部分产品现货库存。银行转账、电汇、支票、现金,在线支付宝及网银支付...
made up of a light chain protein, L-typeAmino acid Transporter, LAT1 (SLC7A5) orLAT2(SLC7A8), covalently linked to a heavy chaintransmembrane protein, 4F2hc/CD98 (SLC3A2).Protein expressionof LAT1 and 4F2hc increases in the placenta from mid-gestation to term (Okamoto et al., 2002...
The in vivo significance of this system in L-DOPA transport across the BBB is indirectly revealed by the decreased effectiveness of the drug after a protein-rich meal in humans. System y+ is the primary cationic amino acid transporter of the BBB. It has an affinity for amino acids with ...
The amino acid sequence of the ASCT1 transporter or derivative thereof preferably consists essentially of the amino acid sequence of the human ASCT1 transporter protein shown in FIG. 1 (SEQ ID No:3). In a second aspect, the invention provides a nucleic acid having a nucleotide sequence ...