L-type amino acid transporter 2 (Lat2, ) is a 12-transmembrane transporter that mediate transport of neutral amino acids and thyroid hormones. LAT2 is expressed along the basolateral membrane of kidney proximal tubulus in humans and mice. In the brain, Lat2 is expressed in neurons, microglia...
Yoshie Reien 1 , Yuri Hirayama 1 , Hirofumi Hashimoto 1 and Naohiko Anzai 1,2* Abstract L-type amino acid transporter 2 (LAT2) is a Na + -independent neutral amino acid
The deducedamino acidsequence from the cDNA fragment contained the signature motifs for the mitochondrial transporter [...] actazool.org actazool.org 推测的此部分氨基酸序列包含线粒体载体蛋白的特征结构,并与其它脊椎动物UCP2氨基酸序列同源性在72 8%以上。
目的研究广西眼镜蛇中提取的L-氨基酸氧化酶(L-aminoacid oxidase)在人体外及家兔体内的抗血小板聚集作用。方法用比浊法测定广西眼镜蛇毒L-氨基酸氧化酶对二磷酸腺苷(A... 王辉,黎肇炎,黄江南 - 《蛇志》 被引量: 2发表: 2008年 广西眼镜蛇毒L-氨基酸氧化酶的分离纯化及体内外抗血小板聚集实验 目的:从广西眼...
Compared to most normal cells that express L-type amino acid transporter 2, L-type amino acid transporter 1 is highly expressed in cells and presumed to support their elevated growth and proliferation. This study examined JPH203, a potent and selective L-type amino acid transporter 1 inhibitor,...
Analysis of L-type amino acid transport expression of hepatocellular carcinoma cells (HCCs) of the dog was performed. The leucine transport activity of canine HCCs was 0.628 ± 0.018 nmol/mg protein/min. The inhibitor of LAT 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (BCH) reduce...
When expressed in Xenopus oocytes, the encoded protein designated LAT3 (L-type amino acid transporter 3) transported neutral amino acids such as l-leucine, l-isoleucine, l-valine, and l-phenylalanine. The LAT3-mediated transport was Na+-independent and inhibited by 2-aminobicyclo[2.2.1]...
Placental amino acid transporters and peroxisome proliferator-activated receptors (PPARs) have been implicated to placental development and therefore regulation of fetal growth. We analyzed the correlation between the expression of amino acid transporter
L-type amino acid transporter-1(LAT1) is a member of the sodium-independent amino acid transport system L and transports large branched-chain and aromatic neutral amino acids. 哺乳动物氨基酸的跨膜运输由多种氨基酸转运载体蛋白介导,其中L型氨基酸转运载体1(LAT1)属于L系统,主要转运大分子支链氨基酸和芳...
acidcancermTORC1pathwaytransportThe L-type amino acid transporter (LAT) family are Na(+)-independent transporters, which deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 (SLC43A1) and LAT4 (SLC43A2), are responsible for the majority of ...