Gamma-aminobutyric acid transporter 1 negatively regulates T cell-mediated immune responses and ameliorates autoimmune inflammation in the CNS. J Immunol 2008; 181: 8226–8236. 17. Dionisio L, Jose De Rosa M, Bouzat C, Esandi Mdel C. An intrinsic GABAergic system in human lymphocytes. ...
another amino acid transporter expressed in DH44+neurons, showed similar results in blocking the increase in food consumption induced by dietary amino acids (Fig.7b).
Bailey C.G. Potter S.J. Cavanaugh J.A. Rasko J.E. Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19.Nat. Genet. 2004; 36: 1003-1007Crossref PubMed Scopus (210) Google Scholar). Monocarboxylate transporter fusion constructs rMCT1-B0...
In contrast, threo-β-hydroxyaspartate (THA) and by L-trans-pyrrolidine-2,4-dicarboxylic acid downregulates this transporter (Arriza et al., 1997). Show abstract Regulation of the Na+-coupled glutamate transporter EAAT3 by PIKfyve 2009, Neurochemistry International Show abstract Regulation of ...
Retinoic acid early transcript 1 L protein structure with PDB ID 4s0u.1.C was used as a template in modelling the ULBP2 protein structure. Also, the SWISS-MODEL workspace provided the QMEAN [20] score. Added to this, the stereochemical quality and reliability of the protein structure were...
2012). The activity of the lysosomal proton-assisted amino acid transporter PAT1, responsible for the efflux of amino acids from the lysosomes, may control the concentration of amino acids within the lysosomal lumen and thus the extent of MTORC1 activation (Zoncu et al. 2011), but the ...
(Fig.1b). Subsequently, the neuronal glutamine transporter fromRattus norvegicus, the sodium-coupled neutral amino acid transporter, and intracellular vacuolar amino acid transporters 2 (AVT2) and 6 (AVT6) fromS. cerevisiaewere found to be high-scoring hits in a BLASTP search of the TCDB ...
This finding raises the possibility that there may be other amino acid transporters that are able to directly communicate the availability of specific amino acids to the Rag GTPases. Indeed, another lysosomal membrane-resident, small unbranched amino acid transporter, proton-assisted amino acid ...
and various tumor cells are the most urgent consumers of Gln.122,123,124Gln enters the cell via the amino acid transporter ASCT2/SLC1A5 and is converted to glutamate in the mitochondria by a deamination reaction involving glutaminase (GLS). Glutamate is then catalyzed by glutamate dehydrogenase ...
Finally, glutamine indirectly participates in mTORC1 activation by acting as the key amino acid for the uptake of leucine (Fig.3d). The solute carrier family 1 member 5 (SLC1A5), a high-affinity transporter for neutral amino acids, is required for glutamine uptake. On the other hand, glutam...