LAT1表现出高度特异性和亲和性,对大多数中性氨基酸如亮氨酸、异亮氨酸、色氨酸等具有高效的转运能力。 二、LAT1重组蛋白的生物学功能:1. 氨基酸转运:LAT1作为一种重要的氨基酸载体蛋白,在细胞内外之间调节氨基酸的平衡。其高效的转运性能能够加速体内氨基酸的摄取和利用,促进蛋白质的合成和能量代谢。2. 治疗:研究表明,...
Transport of a neurotoxicant by molecular mimicry: the methyl- mercury-l-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT 2. Biochem. J. 367, 239 - 246.Simmons-Willis TA, Koh AS, Clarkson TW, Ballatori N. Transport of a neuro- ...
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large neutral amino acid transporter 1 (which is expressed in most tumours), selectively accumulate in human tumour xenografts in mice and in an orthotopic mouse model of human glioma. The functionalized quantum dots, which structurally mimic large amino acids and can be loaded with aromatic drugs...
The system large amino acid transporter (LAT) is a major nutrient transport system that is responsible for Na+-independent transport of large neutral amino acids [9, 10]. It plays a critical role in the absorption of amino acids from the small intestine, as well as in movement of amino ...
Large Network Administration Large Network Project Management Large neutral amino acid transporter Large neutral amino acid-transporter 1 ▼Complete English Grammar Rules is now available in paperback and eBook formats. Make it yours today! Advertisement. Bad banner? Please let us know Remove AdsFace...
(large amino transporter, LAT1), which carries all large neutral amino acids (LNAA) across the blood–brain barrier and is regulated by the availability of tryptophan and other LNAAs competing for the transporter. Therefore, manipulation of dietary tryptophan content by depletion or supplementation ...
SLC7A5 encodes a large amino-acid transporter, which is responsible for the cellular uptake of amino acids, especially large neutral amino acids, such as l-leucine [23]. SLC7A5 (also known as LAT1) modulates cell growth, cell proliferation as well as other intracellular processes in tumors ...
A cDNA was isolated from rat C6 glioma cells by expression cloning which encodes a novel Na+-independent neutral amino acid transporter designated LAT1. For functional expression in Xenopus oocytes, LAT1 required the heavy chain of 4F2 cell surface antigen (CD98), a type II membrane ...
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