LAT1表现出高度特异性和亲和性,对大多数中性氨基酸如亮氨酸、异亮氨酸、色氨酸等具有高效的转运能力。 二、LAT1重组蛋白的生物学功能:1. 氨基酸转运:LAT1作为一种重要的氨基酸载体蛋白,在细胞内外之间调节氨基酸的平衡。其高效的转运性能能够加速体内氨基酸的摄取和利用,促进蛋白质的合成和能量代谢。2. 治疗:研究表明,...
Giacomini, Structure- based ligand discovery for the large-neutral amino acid transporter 1, LAT-1. Proc. Natl. Acad. Sci. U.S.A. 110, 5480-5485 (2013).Geier EG, Schlessinger A, Fan H et al (2013) Structure-based ligand discovery for the large-neutral amino acid transporter 1, LAT-...
The system large amino acid transporter (LAT) is a major nutrient transport system that is responsible for Na+-independent transport of large neutral amino acids [9, 10]. It plays a critical role in the absorption of amino acids from the small intestine, as well as in movement of amino ...
central nervous system neurotransmission relies on serotonin synthesis in the cells of the raphe nuclei. Tryptophan crosses into the brain via a transport protein complex (large amino transporter, LAT1), which carries
A cDNA was isolated from rat C6 glioma cells by expression cloning which encodes a novel Na+-independent neutral amino acid transporter designated LAT1. For functional expression in Xenopus oocytes, LAT1 required the heavy chain of 4F2 cell surface antigen (CD98), a type II membrane ...
SLC7A5 encodes a large amino-acid transporter, which is responsible for the cellular uptake of amino acids, especially large neutral amino acids, such as l-leucine [23]. SLC7A5 (also known as LAT1) modulates cell growth, cell proliferation as well as other intracellular processes in tumors ...
27 Reig N, del Rio C, Casagrande F et al: Functional and structural characterization of the first prokaryotic member of the L-amino acid transporter (LAT) family: a model for APC transporters. J Biol Chem 2007; 282: 13270 – 13281. 28 Stiburek L, Fornuskova D, Wenchich L, Pejz...
endopeptidase (neutral endopeptidase, enkephalinase) GCB NM_012446 23635 SSBP2 single-stranded DNA 203787_at binding protein 2 GCB NM_024613 79666 PLEKHF2 pleckstrin homology 222699_s_at domain containing, family F (with FYVE domain) member 2 GCB AV705976 Transcribed locus 204681_s_at GCB NM_01...
large neutral amino acid transporter 1 (which is expressed in most tumours), selectively accumulate in human tumour xenografts in mice and in an orthotopic mouse model of human glioma. The functionalized quantum dots, which structurally mimic large amino acids and can be loaded with aromatic drugs...
Migraine is a complex neurovascular disease with a range of severity and symptoms, yet mostly studied as one phenotype in genome-wide association studies (GWAS). Here we combine large GWAS datasets from six European populations to study the main migraine