Novel routes for the preparation of acetonylbenzamides are provided by the reaction of an amine and acyl chloride. Novel routes to various intermediates used in the manufacture of acetonylbenzamides are also disclosed.Enrique Luis Michelotti
The Polonovski reaction occurs when an amine oxide reacts with an acylating agent.39 The accepted mechanism involves proton removal to give a nitrogen ylide which loses acetate (using acetic anhydride) which attacks the carbon adjacent to the nitrogen atom giving an α-acetoxyamine. These intermedi...
The process mechanism is based on the governing reaction between carbon dioxide and the chemical solvent, which may be an aqueous solution of mono-, di-, and tri-amine and di-isopropanol amine, among others. In this particular process, absorption and desorption columns (absorbers and regenerator...
The B and D rings of 4 would be formed by a sequential cyclization reaction of amide and pyrrole nitrogen with the imine and methyl esters of 5, respectively. As the acylimine moiety of 5 is highly electron deficient, the nucleophilic addition of amide anion to the C10 carbon centre would...
There are a variety of possible other synthetic routes to carbonyl-oxazoles, including selective reductive addition of hydrides (MetHn) and organometallic reagents (RMGX, RLi, R3Al, etc.) to oxazole-acyl-derivatives (LG=OH, OR, X, NR2), as shown in Schemes E5 and F5, selective oxidation...
Sci. 23(3):197-203 (1968), report the synthesis of several alkyl- and acyl-derivatives of N-amino-1-ephedrine and N-amino-d-pseudoephedrine having antidepressant and monoamine oxidase inhibitory properties. Among the compounds disclosed is the hydrazone erythro-(β-hydroxy-α-methylphenethyl)...
Amination of an indole acyl chloride; tris(2-[indole-3-amido]ethyl)amineSp, Syntheticpage
Although the structure of this enzyme from a dinitrifying Azoarcus strain has been solved [35], its mechanism and the reason(s) for the different behaviour compared to YerE (CC bond cleavage versus ligation) are not known. In addition to the above described various 1,2-additions of carbonyl...
The reaction mechanism of the α-methoxylation or α-acetoxylation of amides61 and carbamates59 has been shown to involve direct one-electron removal from the lone pair electrons of the nitrogen atom in the initial step when inert supporting electrolytes are used. The anodic oxidation of piperidi...
“Mechanism of adjuvant activity of cationic liposome: phosphorylation of a MAP kinase, ERK and induction of chemokines”Mol Immunol 2007;44:3672-81. Zhou et al. “Liposome-mediated cytoplasmic delivery of proteins: an effective means of accessing the MHC class I-restricted antigen presentation ...