Until now a few diagnostic biomarkers for AD have been identified, which can be divided in two groups: protein markers and genetic markers. The most significant protein biomarkers are levels of tau proteins, ubiquitin and amyloid beta-peptides in cerebrospinal fluid (CSF). Among genetic AD ...
Therefore, with the advancements in computational biology approaches, it is possible to combat alzheimer's disease by targeting one of the kinases i.e. GSK-3 ~2 involved in hyper phosphorylation of tau (a reliable marker of neurodegenerative disorders). In this study, we have carried out ...
Protein-Serine-Threonine KinasesAmyloid beta-PeptidesAlzheimer's disease is characterized by pathological aggregation of protein tau and amyloid-β peptides, both of which are considered to be toxic to neurons. Naturally occurring dietary flavonoids have received considerable attention as alternative ...