The present findings in the aged bison parallel previously obtained results from a quantitative study of human brains affected by Alzheimer's disease. In conclusion, the low susceptibility of different types of neurons to the abnormal phosphorylation of tau corresponds to high proportions of certain ...
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans THE paired helical filament (PHF) is the major component of the neurofibrillary deposits that form a defining neuropathological characteristic of Alzheimer... M Goedert,R Jakes,MG Spillant...
积累的超磷酸化tau蛋白,细胞外 翻译结果2复制译文编辑译文朗读译文返回顶部 被hyperphosphorylated 的希腊语的第十九个字母蛋白质的聚积,细胞外 翻译结果3复制译文编辑译文朗读译文返回顶部 hyperphosphorylated Tau 蛋白、 细胞外的积累 翻译结果4复制译文编辑译文朗读译文返回顶部 累积的hyperphosphorylated头蛋白质、细胞外...
Alzheimer's disease (AD) is an age-related neurodegenerative disease marked by a progressive cognitive decline. Metabolic impairments are common hallmarks of AD, and amyloid-β (Aβ) peptide and hyperphosphorylated tau protein—the two foremost histopathological signs of AD—have been implicated in ...
Abnormal phosphorylation (“hyperphosphorylation”) and aggregation of Tau protein are hallmarks of Alzheimer disease and other tauopathies, but their causative connection is still a matter of debate. Tau with Alzheimer-like phosphorylation is also present in hibernating animals, mitosis, or during ...
Hyperphosphorylated tau has been associated in this process, and protein phosphatase 2A 55 kDa regulatory B subunit (PP2A/PR55) - the major tau phosphatase-is decreased after a brain insult. Sodium selenate up-regulates PP2A/PR55 and dephosphorylates tau, and may hold promise as a treatment ...
tau proteinα-synucleinThe aim of this study was to investigate the neuropathological features of the spinal cord in patients suffering with Alzheimer's disease (AD). Spinal cord tissue collected from three AD patients and eight controls was selected for the study. Data were collec...
Hyperphosphorylated tau proteinNeuroinflammationAβ42GliosisBoth neurofibrillary tangles and senile plaques are associated with inflammation in Alzheimer's disease (AD). Their relative degree of induced neuroinflammation, however, is not well established. Mouse models of AD that expressed either human Aβ...
It has been hypothesised that tau protein, when hyper-phosphorylated as in Alzheimer's disease (AD), does not bind effectively to microtubules and is no longer able to stabilise them; thus microtubules break down, and axonal transport can no longer proceed efficiently in affected brain regions ...
tau proteinThe pathological emblems of Alzheimer's disease are the accumulation of amyloid-beta plaques and neurofibrillary tangles. The alluvium of toxic amyloid-beta-protein in the form of aggregates is central to the pathogenesis of Alzheimer's disease. The aggregate formation is due to the ...