LRK10L genes, Alternative promoter, Alternative splicing, Mini-exon, Subcellular localisationKey message AtLRK10L1.2 produces a variety of alternatively spliced variants in the region a mini-exon and skipping of the mini-exon alters the subcellular localization of the protein. Abstract We have ...
Alternative splicing (AS) of pre-mRNAs in higher eukaryotes and several viruses is one major source of protein diversity. Usually, the following major subtypes of AS are distinguished: exon skipping, intron retention, and alternative 3′ and 5′ splice sites. Moreover, mutually exclusive exons (...
可变剪接(alternative splicing),在真核生物中是一种非常基本的生物学事件。即基因转录后,先产生初始RNA或称作RNA前体,然后再通过可变剪接方式,选择性的把不同的外显子进行重连,从而产生不同的剪接异构体(isoform)。这种方式,使得一个基因可产生多个不同的转录本,这些转录本分别在细胞/个体分化发育的不同阶段,在不...
Alternative splicing (AS) of pre-mRNAs in higher eukaryotes and several viruses is one major source of protein diversity. Usually, the following major subtypes of AS are distinguished: exon skipping, intron retention, and alternative 3′ and 5′ splice sites. Moreover, mutually exclusive exons (...
KHSRP ameliorates acute liver failure by regulating pre-mRNA splicing through its interaction with SF3B1 Mingxuan Li Qian Fang Rui Zhou ResearchOpen Access26 Aug 2024Cell Death & Disease Volume: 15, P: 618 Transcriptome- and proteome-wide effects of a circular RNA encompassing four early exons of...
Alternative splicing (AS) of pre-mRNAs in higher eukaryotes and several viruses is one major source of protein diversity. Usually, the following major subtypes of AS are distinguished: exon skipping, intron retention, and alternative 3′ and 5′ splice sites. Moreover, mutually exclusive exons (...
可变剪接(alternative splicing),在真核生物中是一种非常基本的生物学事件。即基因转录后,先产生初始RNA或称作RNA前体,然后再通过可变剪接方式,选择性的把不同的外显子进行重连,从而产生不同的剪接异构体(isoform)。这种方式,使得一个基因可产生多个不同的转录本,这些转录本分别在细胞/个体分化发育的不同阶段,在不...
Alternative splicing is a process by which different combinations of exons are joined together and result in the production of multiple forms of mRNA from a single pre-mRNA (Blencowe 2006). The completion of the human genome project revealed a discord between the genome and the proteome with ...
Human genome encodes a surprisingly low number of genes; however a large transcriptome has been reported for human [1–3]. Alternative splicing of exons, during the processing of pre-mRNA, is a major contributor to the diversity seen in transcriptome and proteome [4, 5]. Transcript isoforms ...
Recently, we showed that Hu proteins participate in epigenetic regulation of the Neurofibromatosis type 1 (NF1) exon 23a splicing by directly interacting with HDAC2 and inhibiting its deacetylation activity to induce local histone hyperacetylation surrounding exon 23a, leading to increased local ...