Biochemistry Introns and alternative splicing in choanoflagellates UNIVERSITY OF CALIFORNIABERKELEY Nicole King WestbrookMarjorie WrightThe first organisms to evolve were unicellular, and the vast majority of l
Most human genes encode multiple mRNA variants and protein products through alternative splicing of exons and introns during pre-mRNA processing. In this way, alternative splicing amplifies enormously the coding potential of the human genome and represents a powerful evolutionary resource. Nonetheless, the...
More importantly, this characteristic of splicing factors often appears to be strongly position-dependent [31]. For example, a splicing factor would serve as a splicing suppressor or an activator in different pre-mRNAs depending on whether it is bound to exons or introns. A well-studied splicing...
A conserved role for intragenic DNA methylation in alternative pre-mRNA splicing. Transcription 3, 106–109 (2012). PubMed PubMed Central Google Scholar Amit, M. et al. Differential GC content between exons and introns establishes distinct strategies of splice-site recognition. Cell Rep. 1, ...
Exons are indicated as boxes, introns as thin lines. Splicing regulator elements (enhancers or silencers) are shown as green or red boxes in exons. The 5′ splice-site (CAGguaagu) and 3′ splice-site (y)10ncagG, as well as the branch point (ynyyray), are indicated (y = c or u...
Alternative splicing (AS) is an important post-transcriptional process that generates RNA isoforms, leading to transcriptome diversity. AS refers to alternative usage of exons and introns, thus consequently altering the protein structure or abundance5. The role of AS in organ development and tumorigenes...
Main article:RNA splicing主要文章:RNA剪接 Spliceosome A complex defines the 5' and 3' ends of the intron before removal[3] 剪接体的复合物定义了内含子的5'和3'末端去除前[3] When the pre-mRNA has been transcribed from theDNA, it includes severalintronsandexons. (Innematodes, the mean is ...
alternativesplicingobserved,ofwhichthemostcommonisexonskipping.Inthis mode,aparticularexonmaybeincludedinmRNAsundersomeconditionsorin [1]particulartissues,andomittedfromthemRNAinothers. 可变剪接的发生是由于在真核生物正常现象,在那里它大大增加了可通过基因 ...
Alternative intron splicing is a process where introns are excised from pre-mRNA following different patterns. The consequence of it is a presence of several different forms of mature mRNAs differing in length and in content of the whole exons or their parts. Studies in the past decade lead ...
governalternativesplicinginhumanswillbededuced. Introduction Inthehumangenome,theproteincodingsequenceofmostgenesisorganizedintodiscreteblocksof sequence,theexons,whichareinterruptedbynoncodingsequencescalledintrons.Exonsandintronsare transcribedtogetheraslongnuclearpre-mRNAsthatmustbesplicedsoastoexcisetheintronsandligatethe...