DRUG-DELIVERYBIOEQUIVALENCESUSPENSIONSYSTEMIMPACTClozapine is the only antipsychotic with proven effectiveness in treatment-resistant schizophrenia. It is usually administered using commercially available oral tablets, but not all patients are willing or able to take medicines in this way. Orodispersible ...
Treatment failure with clozapine: Can olanzapine be the alternative therapy? Background: Tinnitus is a common problem for which many treatments have been proposed and implemented. Patients tend to seek renewed treatment after treatm... GD Tollefson,PV Tran,M Birkett,... - 《Schizophrenia Research...
If an antiepileptic-drug-induced psychosis does occur then it might be necessary either to decrease the dose of the drug or to withdraw it completely. In this context, it is important to discuss the concepts of “forced normalization” and “reciprocal psychosis” or “alternative psychosis.”“...
The use of alternative specimens in the field of toxicology was first described in 1979, when hair analysis was used to document chronic drug exposure. Sin... E Gallardo,JA Queiroz - 《Biomedical Chromatography》 被引量: 190发表: 2008年 Determination of "Ecstasy" components in alternative biolog...
drugs. Tacrolimus was a calcineurin inhibitor. Sirolimus inhibits the response to IL-2, and thereby blocks activation of T- and B-cells. They can also ameliorate fibrosis [23,24]. Mesalazine was also an anti-inflammatory drug [25]. These results showed the known effects of Fuzheng Huayu ...
13% of the patients had died (mean age 49 years) at some point following clozapine discontinuation. In terms of the alternative antipsychotic prescribing, olanzapine was the most commonly prescribed (37.1%) drug in patients who were still under the care of the local psychiatric service (n=121...
This may have consequences for the pharmacokinetic profile of the generic drug. A higher maximum plasma concentration (Cmax) could lead to increased or emergent adverse effects, whereas a decreased absorption or minimum plasma concentration (Cmin) may result in a reduced therapeutic effect. For ...
This may have consequences for the pharmacokinetic profile of the generic drug. A higher maximum plasma concentration (C(max)) could lead to increased or emergent adverse effects, whereas a decreased absorption or minimum plasma concentration (C(min)) may result in a reduced therapeutic effect. ...
Ms. M. was given a trial of clozapine in 1992 after failure to respond to a multitude of drug regimen. After 6 weeks on 100 mg/day of clozapine, Ms. M. developed an agranulocytosis (neutrophils 0.088 GI/L) with profound leukopenia (WBC 0.86 GI/L). The diagnosis of agranulocytosis ...
Treatment failure with clozapine: Can olanzapine be the alternative therapy? Background: Tinnitus is a common problem for which many treatments have been proposed and implemented. Patients tend to seek renewed treatment after treatm... GD Tollefson,PV Tran,M Birkett,... - 《Schizophrenia Research...