Alpha-mannosidase II (MAN2A1) and alpha-mannosidase IIx (MAN2A2) are key enzymes that convert precursor high mannose-type N -glycans to mature complex-type structures. While alpha-mannosidase II activity had been characterized by the time the mechanism of N -glycan processing was recognized (...
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Alpha-mannosidase IIx (MX) is an enzyme closely related to the Golgi N-glycan processing enzyme alpha-mannosidase II (MII). The enzymatic activity of MX in... Michiko N,Fukuda,Tomoya O,Akama - 《Biochimica Et Biophysica Acta General Subjects》 被引量: 3发表: 2019年 ...
Whereas kifunensine (16, Scheme 6) binds to α-mannosidase I as a strong inhibitor in the 1C4 chair conformation, it is a rather poor inhibitor of Golgi α-mannosidase II (Ki 5.2 mM), where it was found to complex as a 1,4B boat (PDB 1PS3).286 1-Deoxymannojirimycin (11), con...
(Schatzle et al., 1992); 5, human lysosomal α-mannosidase (=-=Nebes and Schmidt, 1994-=-); 6, mouse lysosomal α-mannosidase (Merkle and Moreman, 1993); 7, Drosophila melanogaster Golgi mannosidase II (Foster et al., 1995); 8, human Golgi mannosidase II (Misago et al. 1995); ...
Here we demonstrate that this region is responsible for Golgi localization and in doing so confirm that endomannosidase is a type II membrane protein, like the majority of other secretory pathway glycosylation enzymes. 展开 关键词: glycosidase glycosylation Pichia pastoris recombinant expression ...
Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells MannosidasesAntineoplastic AgentsPhytogenicEnzyme Inhibitors1-Deoxynojirimycin甘露糖苷酶类Golgi alpha-mannosidase II, a key enzyme in N-glycan processing, is a... JM Van-Den-Elsen,DA Kuntz,DR...
EndotoxinLess than 0.1 ng/μg (1 EU/μg) as determined by LAL test. BackgroundEndoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1...
Current evidence indicates that the trimming of mannosyl residues from intermediates in the biosynthesis of the N-linked oligosaccharides of glycoproteins occurs in the Golgi complex. We now present evidence that mannosidase II (Tulsiani, D. R. P., Opheim, D. J., and Touster, O. (1977) J...
The enzyme activity is inhibited by swainsonine and 1-deoxymannojirimycin at concentrations 50-500-fold higher than required for complete inhibition of Golgi-mannosidase II and mannosidase I, respectively. The data indicate strongly that the enzyme has novel activity and is distinct from previously ...