Alpha-mannosidase-II defi- ciency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis. Cell. 1997;90:157-167.Chui, D., Oh-Eda, M., Liao, Y.-F., Panneerselvam, K., Lal, A., Marek, K.W., Freeze, H.H., Moremen, K.W., Fukuda, M.N., ...
The same mechanism could contribute to the increased prevalence of autoimmune disorders among mannosidosis patients ([13] and Malm D: personal observations). Interestingly, in a mice model, alpha-mannosidase II deficiency reduces complex-type N-glycan branching and induces an autoimmune disease simila...
In vivo role of α-mannosidase IIx: ineffective spermatogenesis resulting from targeted disruption of the Man2a2 in the mouse. Alpha-mannosidase IIx (MX) is an enzyme closely related to the Golgi N-glycan processing enzyme聽伪-mannosidase II (MII). The enzymatic activity of MX in v... Fukuda...
Proc. Natl. Acad. Sci. USAVol. 80, pp. 4364-4368, July 1983Cell BiologyImmunocytochemical localization of c-D-mannosidase II in theGolgi apparatus of rat liver(glycoprotein-processing enzymes/staphylococcal protein A-peroxidase cytochemistry/endoplasmic reticulum/lysosomes/GERL)PHYLLIS M. NOVIKOFF*, D...
Here we demonstrate that this region is responsible for Golgi localization and in doing so confirm that endomannosidase is a type II membrane protein, like the majority of other secretory pathway glycosylation enzymes. 展开 关键词: glycosidase glycosylation Pichia pastoris recombinant expression ...
Only patients with the mild form (type II) were entered into this study if they had a documented deficiency of serum or leukocyte acid alpha-Mannosidase enzyme activity level. Patients had to be excluded from the study if they had received a bone marrow transplantation or had used an investiga...
Andria, G. and Sly, W. S. 1981. Intermediate Golgi a-mannosidase activity in fibroblasts from patients with mannosidosis and mucolipidosis II and III. Pediatr. Res. 15 : 70-73.ANDRIA G, SLY WS: Intermediate Golgi a-D-mannosidase activity in fibroblasts from patients with mannosidosis ...
NOVEL ALPHA-1,3-MANNOSIDASE AND PRODUCTION THEREOF 优质文献 相似文献Inhibitors of carbohydrate processing: A new class of anticancer agents. Of the carbohydrate-processing inhibitors presently available, the alkaloid swainsonine, a Golgi alpha-mannosidase II inhibitor, is the first to have been ... ...
The oil and gas well stimulation require in situ enzymatic hydrolysis of guar gum by α-galactosidase and β-mannosidase in deep, hot wells, which demands the use of thermostable and thermoactive enzymes that can operate at extremely high temperatures (Ma et al., 2021). The combinations of ...
Purification and properties of alpha-D-mannose:beta-1,2-N-acetylglucosaminyl-transferases and alpha-D-mannosidases from human adenocarcinoma. Two specific N-acetylglucosaminyltransferases, alpha-1,3-mannoside:beta-2-N-acetylglucosaminyltransferase (transferase I) and alpha-1,6-mannoside:beta-2-N...