The invention relates to compositions containing an inhibitor of the Golgi enzyme 伪-mannosidase II and which may contain an interferon or interferon inducer and to the use of such compositions for the production of medicaments for use in methods of preventing and treating diseases, such as ...
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Alpha-mannosidase IIx (MX) is an enzyme closely related to the Golgi N-glycan processing enzyme alpha-mannosidase II (MII). The enzymatic activity of MX in... Michiko N,Fukuda,Tomoya O,Akama - 《Biochimica Et Biophysica Acta General Subjects》 被引量: 3发表: 2019年 ...
α-Mannosidase II (MII) is a key enzyme in the production of complex-type glycans (Figure 5). The knockout of MII abolishes complex-type glycans in erythrocytes, while in many organs, complex-type glycans continue to be expressed to various degrees.16 This observation has led to the identif...
(Schatzle et al., 1992); 5, human lysosomal α-mannosidase (=-=Nebes and Schmidt, 1994-=-); 6, mouse lysosomal α-mannosidase (Merkle and Moreman, 1993); 7, Drosophila melanogaster Golgi mannosidase II (Foster et al., 1995); 8, human Golgi mannosidase II (Misago et al. 1995); ...
Here we demonstrate that this region is responsible for Golgi localization and in doing so confirm that endomannosidase is a type II membrane protein, like the majority of other secretory pathway glycosylation enzymes. 展开 关键词: glycosidase glycosylation Pichia pastoris recombinant expression ...
Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells MannosidasesAntineoplastic AgentsPhytogenicEnzyme Inhibitors1-Deoxynojirimycin甘露糖苷酶类Golgi alpha-mannosidase II, a key enzyme in N-glycan processing, is a... JM Van-Den-Elsen,DA Kuntz,DR...
BackgroundEndoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoprote...
Current evidence indicates that the trimming of mannosyl residues from intermediates in the biosynthesis of the N-linked oligosaccharides of glycoproteins occurs in the Golgi complex. We now present evidence that mannosidase II (Tulsiani, D. R. P., Opheim, D. J., and Touster, O. (1977) J...
The enzyme activity is inhibited by swainsonine and 1-deoxymannojirimycin at concentrations 50-500-fold higher than required for complete inhibition of Golgi-mannosidase II and mannosidase I, respectively. The data indicate strongly that the enzyme has novel activity and is distinct from previously ...