The invention relates to compositions containing an inhibitor of the Golgi enzyme 伪-mannosidase II and which may contain an interferon or interferon inducer and to the use of such compositions for the production of medicaments for use in methods of preventing and treating diseases, such as ...
Andria, G. and Sly, W. S. 1981. Intermediate Golgi a-mannosidase activity in fibroblasts from patients with mannosidosis and mucolipidosis II and III. Pediatr. Res. 15 : 70-73.ANDRIA G, SLY WS: Intermediate Golgi a-D-mannosidase activity in fibroblasts from patients with mannosidosis ...
Current evidence indicates that the trimming of mannosyl residues from intermediates in the biosynthesis of the N-linked oligosaccharides of glycoproteins occurs in the Golgi complex. We now present evidence that mannosidase II (Tulsiani, D. R. P., Opheim, D. J., and Touster, O. (1977) J...
The invention relates to compositions containing an inhibitor of the Golgi enzyme alpha -mannosidase II and which may contain an interferon or interferon inducer and to the use of such compositions for the production of medicaments for use in methods of preventing and treating diseases, such as ...
Members of GH38, including Golgi a-mannosidase II and Golgi α-mannosidase IIx, reside in the Golgi complex (Igdoural et al. 1999) and act to cleave two additional terminal mannose residues (Man-α1,3Man and Man-α1,6Man) to yield the GlcNAcMan 3 GlcNAc 2 -Asn intermediate necessary ...
The invention relates to compositions containing an inhibitor of the Golgi enzyme alpha -mannosidase II and which may contain an interferon or interferon inducer and to the use of such compositions for the production of medicaments for use in methods of preventing and treating diseases, such as ...
Structure of Golgi alpha- mannosidase II : a target for inhibition of growth and metastasis of canc- er cells[J]. EMBO J, 2001,20(12) : 3008 -3017.VAN DEN ELSEN JM,KUNTZ DA, ROSE DR. Structure of Golgi alpha-mannosidase Ⅱ:a target for inhibition of growth and metastasis of cancer...
RoseD.R.ShahN.KuntzD.A.GLYCOCONJUGATE JOURNAL
The synthesized new architectures show a remarkable multivalent effect towards GMIIb, the recombinant Drosophila homolog of the tumor over-expressed human Golgi 伪-mannosidase II, over other 伪-mannosidases. Computational studies shed light on the origin of their multivalent effect as well as on ...
Kuntz DA,Nakayama S,Shea K,et al.Structural investigation of the binding of5-substituted swainsonine analogues to Golgi alpha-mannosidase II. ChemBioChem . 2010Structural investigation of the binding of5-substituted swainsonine analogues to Golgi alpha-mannosidase II. Kuntz DA,Nakayama S,Shea K,et ...