Alpha-mannosidase-II defi- ciency results in dyserythropoiesis and unveils an alternate pathway in oligo- saccharide biosynthesis. Cell 90, 157e167.Chui, D., Oh-Eda, M., Liao, Y.F., Panneerselvam, K., Lal, A., Marek, K.W., Freeze, H.H., Moremen, K.W., Fukuda, M.N., and...
Nephritis in alpha-mannosidase-II deficient mice 来自 ResearchGate 喜欢 0 阅读量: 15 作者:G Sellakumar,D Chui,M Sutton-Smith,K Marek,JD Marth 摘要: Autoimmune diseases are among the most prevalent of afflictions, yet the genetic factors responsible are largely undefined. Protein glycosylation in...
Proc. Natl. Acad. Sci. USAVol. 80, pp. 4364-4368, July 1983Cell BiologyImmunocytochemical localization of c-D-mannosidase II in theGolgi apparatus of rat liver(glycoprotein-processing enzymes/staphylococcal protein A-peroxidase cytochemistry/endoplasmic reticulum/lysosomes/GERL)PHYLLIS M. NOVIKOFF*, D...
Here we demonstrate that this region is responsible for Golgi localization and in doing so confirm that endomannosidase is a type II membrane protein, like the majority of other secretory pathway glycosylation enzymes. 展开 关键词: glycosidase glycosylation Pichia pastoris recombinant expression ...
Andria, G. and Sly, W. S. 1981. Intermediate Golgi a-mannosidase activity in fibroblasts from patients with mannosidosis and mucolipidosis II and III. Pediatr. Res. 15 : 70-73.ANDRIA G, SLY WS: Intermediate Golgi a-D-mannosidase activity in fibroblasts from patients with mannosidosis ...
Alpha-mannosidase II (MAN2A1) and alpha-mannosidase IIx (MAN2A2) are key enzymes that convert precursor high mannose-type N -glycans to mature complex-type structures. While alpha-mannosidase II activity had been characterized by the time the mechanism of N -glycan processing was recognized (...
The selective hydrolysis of alpha-1,3-mannoside bonds is the hydrolysis of a compound expressed by formula I (R1 is H, monosaccharide or oligosaccharide; R2 is oligosaccharide or glycopeptide; Man is mannose residue) into a compound expressed by formula II. Chemical properties of the alpha-1,3...
The invention relates to compositions containing an inhibitor of the Golgi enzyme 伪-mannosidase II and which may contain an interferon or interferon inducer and to the use of such compositions for the production of medicaments for use in methods of preventing and treating diseases, such as ...
Members of GH38, including Golgi a-mannosidase II and Golgi α-mannosidase IIx, reside in the Golgi complex (Igdoural et al. 1999) and act to cleave two additional terminal mannose residues (Man-α1,3Man and Man-α1,6Man) to yield the GlcNAcMan 3 GlcNAc 2 -Asn intermediate necessary ...
Case studies of alpha-mannosidase-II; Experimental procedures used in the study; Results of the study.ChuiDanielOh-EdaMasayoshiCellChui D, Oh-Eda M, Liao Y-F, Panneerselvam K, Lal A, Marek KW, Freeze HH, Moremen KW, Fukuda MN, Marth JD (1997) Alpha-mannosidase-II deficiency results ...