Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis. Cell 1997; 90:157–67.Chui D, Oh-Eda M, Liao YF, Panneerselvam K, Lal A, Marek KW, et al. Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an ...
Anti-MAN2A2 / Alpha-Mannosidase II Antibody (aa766-796) IHC-plus 供应商 MyBioSource 产品货号 MBS249809 产品报价 ￥询价/0.2mL ￥询价/Null ￥询价/其它规格 产品说明书 点击查看 购买方式 MyBioSource中国区金牌代理,部分产品现货库存。银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联...
Nephritis in alpha-mannosidase-II deficient mice 来自 ResearchGate 喜欢 0 阅读量: 13 作者:G Sellakumar,D Chui,M Sutton-Smith,K Marek,JD Marth 摘要: Autoimmune diseases are among the most prevalent of afflictions, yet the genetic factors responsible are largely undefined. Protein glycosylation in...
Members of GH38, including Golgi a-mannosidase II and Golgi α-mannosidase IIx, reside in the Golgi complex (Igdoural et al. 1999) and act to cleave two additional terminal mannose residues (Man-α1,3Man and Man-α1,6Man) to yield the GlcNAcMan 3 GlcNAc 2 -Asn intermediate necessary ...
Whereas kifunensine (16, Scheme 6) binds to α-mannosidase I as a strong inhibitor in the 1C4 chair conformation, it is a rather poor inhibitor of Golgi α-mannosidase II (Ki 5.2 mM), where it was found to complex as a 1,4B boat (PDB 1PS3).286 1-Deoxymannojirimycin (11), con...
Using the murine cDNA that encodes Golgi alpha-mannosidase II (GlcNAc transferase I-dependent alpha 1,3[alpha 1,6] mannosidase; EC 3.2.1.114) as a probe to screen a cDNA library made from Drosophila melanogaster (Dm) embryos, we have isolated GmII, the Dm sequence homologue. The 3926-bp ...
Here we demonstrate that this region is responsible for Golgi localization and in doing so confirm that endomannosidase is a type II membrane protein, like the majority of other secretory pathway glycosylation enzymes. 展开 关键词: glycosidase glycosylation Pichia pastoris recombinant expression ...
The enzyme activity is inhibited by swainsonine and 1-deoxymannojirimycin at concentrations 50-500-fold higher than required for complete inhibition of Golgi-mannosidase II and mannosidase I, respectively. The data indicate strongly that the enzyme has novel activity and is distinct from previously ...
Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells MannosidasesAntineoplastic AgentsPhytogenicEnzyme Inhibitors1-Deoxynojirimycin甘露糖苷酶类Golgi alpha-mannosidase II, a key enzyme in N-glycan processing, is a... JM Van-Den-Elsen,DA Kuntz,DR...
Current evidence indicates that the trimming of mannosyl residues from intermediates in the biosynthesis of the N-linked oligosaccharides of glycoproteins occurs in the Golgi complex. We now present evidence that mannosidase II (Tulsiani, D. R. P., Opheim, D. J., and Touster, O. (1977) J...