Alpha-1 antitrypsin (AAT), also referred to as 伪 1 -proteinase inhibitor or SERPINA1, is the most abundant serine proteinase inhibitor in human plasma. Genetically determined deficiency of AAT is associated with early-onset emphysema, particularly in individuals who smoke or are exposed to other ...
SomaScan蛋白质组学—揭示Alpha-1 抗胰蛋白酶缺乏症和慢性阻塞性肺疾病肺气肿的独特和共享全身生物标志物 文章题目:Unique and shared systemic biomarkers for emphysema in Alpha-1 Antitrypsin deficiency and chronic obstructive pulmonary disease 中文题目:Alpha-1 抗胰蛋白酶缺乏症和慢性阻塞性肺疾病肺气肿的独特和...
Alpha-1抗胰蛋白酶缺乏症(AAT)的英文名字是Alpha-1 antitrypsin deficiency(AAT)。基因解码表明:Alpha-1抗胰蛋白酶缺乏症(AAT)是一种遗传性疾病,主要影响肺部和肝脏。该疾病由于Alpha-1抗胰蛋白酶(AAT)基因突变导致AAT蛋白质的产量减少或功能异常。分子检测是一种用
Alpha1-antitrypsin deficiency (AATD) was first described by Laurell and Eriksson in 1963. Laurell noted the absence of the band of alpha1- protein in 5 of 1500 serum protein electrophoreses (SPEP) submitted to his laboratory in Sweden.
Alpha-1-antitrypsin deficiency (AATD) is a rare genetic disorder associated with the development of liver and lung disease. AAT is a 52-kD glycoprotein, produced mainly by hepatocytes and secreted into the blood. Agglomeration of the AAT-protein in hepatocytes can result in liver disease. Exposur...
Although alpha1-antitrypsin (AAT) deficiency typically causes emphysema, it also can produce airway obstruction with no evidence of alveolar destruction. Thus, the progressing disease and the growing risk of emphysema may go undiagnosed for years in patients with asthma. In this article, the authors...
Alpha-1抗胰蛋白酶缺乏症的英文名字是Alpha-1 antitrypsin deficiency。基因解码表明:Alpha-1抗胰蛋白酶缺乏症是一种遗传性疾病,与基因突变密切相关。Alpha-1抗胰蛋白酶是一种由SERPINA1基因编码的蛋白质,它在肝脏中合成并通过血液循环分布到全身。该蛋白质的主要功能是
Alpha1-antitrypsin deficiency (AATD) was first described by Laurell and Eriksson in 1963. Laurell noted the absence of the band of alpha1- protein in 5 of 1500 serum protein electrophoreses (SPEP) submitted to his laboratory in Sweden.
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Alpha-1 antitrypsin deficiency (AATD, OMIM #613490) is a rare metabolic disorder affecting lungs and liver. The purpose of this study is to assess the impact of the US orphan drug act on AATD by providing a quantitative clinical-regulatory insight into the status of FDA orphan drug approval...