No treatment is needed for the silent carrier state or for alpha-thalassemia trait, but studies to determine the thalassemia status of other family members, particularly those in their reproductive years, are recommended so that genetic counseling (and prenatal diagnosis if indicated) can be provided...
Treatment depends of the type of thalassemia. The thalassemia traits require no treatment or long-term monitoring. The intermediate types may require occasional RBC transfusions if symptomatic from anemia or if growth is impaired, whereas beta thalassemia major patients will require repeated RBC transfus...
The thalassemias are a group of inherited hematologic disorders caused by defects in the synthesis of one or more of the hemoglobin chains. Alpha tha..
A large number of alpha-thalassemia alleles have been described and their interaction results in the wide spectrum of hematological and clinical phenotypes. Genotype-phenotype correlation has been only partly clarified. Carriers of alpha-thalassemia do not need any treatment. Usually, patients with ...
Define Alpha toxin. Alpha toxin synonyms, Alpha toxin pronunciation, Alpha toxin translation, English dictionary definition of Alpha toxin. n. 1. The first letter of the Greek alphabet. See Table at alphabet. 2. The first of a series; the beginning. 3. A
Can arise as a result of liver disease, iron deficiency or thalassemia. targeting signal Peptide sequence within a protein that determines where in the cell the protein will be located. Thus there are targeting signals for proteins that accumulate in the nucleus, others for ER, lysosomes and so...
but with a special caution for delayed treatment among patients with HbH-HbCS [62]. Deferasirox starting from the dose of 10 mg/kg/day is the chelator of choice for NTDT [60,65]. Affected patients with transfusion-dependent HbH should be chelated according to the thalassemia international fed...
that the individual who has a negative result has a minor OR of having two or more deletions related to α-thalassemia. In our total sample, 63.6% (187/294) of the patients would not need an immediate PCR for the most frequent α-thalassemia deletions. This contributes to the decision-mak...
Bordbar, E.; Taghipour, M.; Zucconi, B.E. Reliability of Different RBC Indices and Formulas in Discriminating between β-Thalassemia Minor and other Microcytic Hypochromic Anemia.Mediterr. J. Hematol. Infect. Dis.2015,7, e2015022. [Google Scholar] [CrossRef] [PubMed] ...